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Rapid molecular syndromic testing for aetiological diagnosis of gastrointestinal infections and targeted antimicrobial prescription: experience from a reference paediatric hospital in Spain
(Springer Nature, 2021)
Aetiological diagnosis of gastrointestinal infections is challenging since a wide range of bacteria, parasites and viruses can be causal agents and derived clinical manifestations appear quite similar. ...
Nasopharyngeal microbiota in children with invasive pneumococcal disease: identification of bacteria with potential disease-promoting and protective effects
(Frontiers Media, 2019)
Background and Aims: The risk of suffering from some infectious diseases can be related to specific microbiota profiles. Specifically, the nasopharyngeal microbiota could play a role as a risk or ...
Exploring the nasopharyngeal microbiota composition in infants with whooping cough: a test-negative case-control study
(Public Library of Science, 2021)
Purpose: The purpose of this study was to characterize the nasopharyngeal microbiota of infants with possible and confirmed pertussis compared to healthy controls. Methods: This prospective study included ...
Reduction of direct health costs associated with pertussis vaccination with acellular vaccines in children aged 0–9 years with pertussis in Catalonia (Spain)
(Springer Nature, 2019)
Objectives: The aim of this study was to assess direct health costs in children with pertussis aged 0–9 years who were vaccinated, partially vaccinated, and unvaccinated during childhood, and to assess ...
Incidence and severity of pertussis hospitalisations in infants aged less than 1 year in 37 hospitals of six EU/EEA countries, results of PERTINENT sentinel pilot surveillance system, december 2015 to december 2018
(European Centre for Disease Prevention and Control, 2021)
Introduction: PERTINENT is a pilot active surveillance system of infants hospitalised with pertussis in six European Union/European Economic Area countries (37 hospitals, seven sites). Aim: This ...
Pneumococcal serotypes in children, clinical presentation and antimicrobial susceptibility in the PCV13 era
(Cambridge University Press, 2020-11)
The aim was to analyse invasive pneumococcal disease (IPD) serotypes in children aged ⩽17 years according to clinical presentation and antimicrobial susceptibility. We conducted a prospective study ...
Pneumococcal nasopharyngeal carriageamong Bhutanese children hospitalizedwith clinical pneumonia: serotypes andviral co-infection
(Springer Nature, 2020-12)
Background: Pneumococcal nasopharyngeal colonization (PNC) generally precedes pneumococcal disease. The purpose of this study was to determine the prevalence of PNC and to identify the pneumococcal ...
Rapid identification, capsular typing and molecular characterization of streptococcus pneumoniae by using whole genome nanopore sequencing
(Springer Nature, 2020)
Background: Whole genome sequencing has emerged as a useful tool for identification and molecular characterization of pathogens. MinION (Oxford Nanopore) is a real-time third generation sequencer whose ...
Genomic and serologic characterization ofenterovirus A71 brainstem encephalitis
(Wolters Kluwer, 2020)
Objective: In 2016, Catalonia experienced a pediatric brainstem encephalitis outbreak caused by enterovirus A71 (EV-A71). Conventional testing identified EV in the periphery but rarely in CSF. Metagenomic ...
Pneumonia in children admitted to the national referral hospital in Bhutan: a prospective cohort study
(Elsevier, 2020-06)
Objectives: The study aim was to describe the etiological profile and clinical characteristics of pneumonia among children hospitalized in Thimphu, Bhutan. Methods: This prospective study enrolled ...