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Critical update for the clinical use of L-carnitine analogs in cardiometabolic disorders
(Dove Press, 2011-03-28)
Acetyl-L-carnitine (ALC) and propionyl-L-carnitine (PLC) are two naturally occurring carnitine derivates formed by carnitine acetyltransferase. The beneficial cardiovascular effects of ALC and PLC have ...
Impaired cerebral autoregulation is associated with brain dysfunction in patients with sepsis
(Springer Nature, 2018-12-04)
Background: Sepsis-associated brain dysfunction (SABD) is associated with high morbidity and mortality. The pathophysiology of SABD is multifactorial. One hypothesis is that impaired cerebral autoregulation ...
Distinct structural transitions of chromatin topological domains correlate with coordinated hormone-induced gene regulation
(Cold Spring Harbor Laboratory Press, 2014)
The human genome is segmented into topologically associating domains (TADs), but the role of this conserved organization during transient changes in gene expression is not known. Here we describe the ...
Hymenal tags of the newborn
(ACT Publishing Group Limited, 2019)
Evaluation of female newborn genitalia should always be carried out at pre-discharge visit in hospital nurseries in order to exclude gross malformations, potentially compatible with genetic and/or ...
An effect of bilingualism on the auditory cortex
(Society for Neuroscience, 2012-11)
Two studies (Golestani et al., 2007; Wong et al., 2008) have reported a positive correlation between the ability to perceive foreign speech sounds and the volume of Heschl's gyrus (HG), the structure ...
Molecular epidemiology of an enterovirus A71 outbreak associated with severe neurological disease, Spain, 2016
(European Centre for Disease Prevention and Control (ECDC), 2019-02)
Enterovirus 71 (EV-A71) is a small, non-enveloped, single-stranded RNA virus that belongs to the species Enterovirus A along with 24 other serotypes within the Enterovirus genus [1]. According to the ...
CPT1C in the ventromedial nucleus of the hypothalamus is necessary for brown fat thermogenesis activation in obesity
(Elsevier, 2019-01)
Objective: Carnitine palmitoyltransferase 1C (CPT1C) is implicated in central regulation of energy homeostasis. Our aim was to investigate whether CPT1C in the ventromedial nucleus of the hypothalamus ...
Molecular evolution of multiple-level control of heme biosynthesis pathway in animal kingdom
(Public Library of Science, 2014)
Adaptation of enzymes in a metabolic pathway can occur not only through changes in amino acid sequences but also through variations in transcriptional activation, mRNA splicing and mRNA translation. The ...
Plataformas digitales y empleo: necesidad de monitorización y vigilancia de Salud Pública
(Ministerio de Sanidad, Consumo y Bienestar Social, 2018)
Actualmente, la relación entre las condiciones del trabajo y empleo con la salud es bien conocida, además esta relación es un importante determinante social de la salud de la población trabajadora ...
Antiretroviral therapy suppressed participants withlow CD4RT-cell counts segregate according toopposite immunological phenotypes
(Wolters Kluwer, 2016-09)
Background:The failure to increase CD4þT-cell counts in some antiretroviral therapysuppressed participants (immunodiscordance) has been related to perturbed CD4þT-cell homeostasis and impacts clinical ...