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Proteasomal-mediated degradation of AKAP150 accompanies AMPAR endocytosis during cLTD
(Society for Neuroscience, 2020-03-23)
The number and function of synaptic AMPA receptors (AMPARs) tightly regulates excitatory synaptic transmission. Current evidence suggests that AMPARs are inserted into the postsynaptic membrane during ...
Manejo de pacientes en cirugía oral y maxilofacial durante el periodo de crisis y de control posterior de la pandemia de COVID-19
(Inspira Network, 2020)
La pandemia por la nueva infección respiratoria conocida como enfermedad coronavirus 2019 (COVID-19), causada por el virus SARS-CoV-2, ha desencadenado una perturbación sin precedentes en la actividad ...
Determining the value of two biologic drugs for chronic inflammatory skin diseases: results of a multi-criteria decision analysis
(Springer Nature, 2018)
Background and Objective: Multi-criteria decision analysis (MCDA) is a tool that systematically considers multiple factors relevant to health decision-making. The aim of this study was to use an MCDA ...
High effectiveness of a 14-day concomitant therapy for helicobacter pylori treatment in primary care. An observational multicenter study
(MDPI, 2020)
Background: The current cure rates with triple therapy combining a proton-pump inhibitor, amoxicillin and clarithromycin are unacceptably low. Aims: To evaluate the efficacy of a 14-day concomitant ...
Effects of sedatives and opioids on trigger and cycling asynchronies throughout mechanical ventilation: an observational study in a large dataset from critically ill patients
(Springer Nature, 2019-07-05)
Background: In critically ill patients, poor patient-ventilator interaction may worsen outcomes. Although sedatives are often administered to improve comfort and facilitate ventilation, they can be ...
Critical update for the clinical use of L-carnitine analogs in cardiometabolic disorders
(Dove Press, 2011-03-28)
Acetyl-L-carnitine (ALC) and propionyl-L-carnitine (PLC) are two naturally occurring carnitine derivates formed by carnitine acetyltransferase. The beneficial cardiovascular effects of ALC and PLC have ...
Does the addition of manual therapy approach to a cervical exercise program improve clinical outcomes for patients with chronic neck pain in short -and mid-term? A randomized controlled trial
(MDPI, 2020)
Chronic neck pain is one of today’s most prevalent pathologies. The International Classification of Diseases categorizes four subgroups based on patients’ associated symptoms. However, this classification ...
Genetic and clinical heterogeneity in thirteen new cases with aceruloplasminemia. Atypical anemia as a clue for an early diagnosis
(MDPI, 2020)
Aceruloplasminemia is a rare autosomal recessive genetic disease characterized by mild microcytic anemia, diabetes, retinopathy, liver disease, and progressive neurological symptoms due to iron accumulation ...
Impaired cerebral autoregulation is associated with brain dysfunction in patients with sepsis
(Springer Nature, 2018-12-04)
Background: Sepsis-associated brain dysfunction (SABD) is associated with high morbidity and mortality. The pathophysiology of SABD is multifactorial. One hypothesis is that impaired cerebral autoregulation ...
Análisis de la evolución en el acceso a los medicamentos huérfanos en España
(Elsevier, 2020)
Objetivo: Evaluar el acceso al mercado de los medicamentos huérfanos en España que a fecha de 31 de diciembre de 2017 tuvieran vigente su designación, y para aquellos comercializados en España estimar ...