Listando Ciències de la Salut por materia "Neurociencias"
Mostrando ítems 1-5 de 5
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Mechanisms of CPT1C-Dependent AMPAR trafficking enhancement
(Frontiers in Molecular Neuroscience, 2018-08-08)In neurons, AMPA receptor (AMPAR) function depends essentially on their constituent components: the ion channel forming subunits and ion channel associated proteins. On the other hand, AMPAR trafficking ... -
Sensing of nutrients by CPT1C controls SAC1 activity to regulate AMPA receptor trafficking
(Journal of Cell Biology, 2020-09)Carnitine palmitoyltransferase 1C (CPT1C) is a sensor of malonyl-CoA and is located in the ER of neurons. AMPA receptors (AMPARs) mediate fast excitatory neurotransmission in the brain and play a key ... -
Sensing of nutrients by CPT1C controls SAC1 activity to regulate AMPA receptor trafficking
(Journal of Cell Biology, 2020)Carnitine palmitoyltransferase 1C (CPT1C) is a sensor of malonyl-CoA and is located in the ER of neurons. AMPA receptors (AMPARs) mediate fast excitatory neurotransmission in the brain and play a key ... -
Sensing of nutrients by CPT1C regulates late endosome/lysosome anterograde transport and axon growth
(eLife, 2019)Anterograde transport of late endosomes or lysosomes (LE/Lys) is crucial for proper axon growth. However, the role of energetic nutrients has been poorly explored. Malonyl-CoA is a precursor of fatty ... -
X-linked Inhibitor of Apoptosis Protein negatively regulates neuronal differentiation through interaction with cRAF and Trk
(Scientific Reports, 2013-08-09)X-linked Inhibitor of apoptosis protein (XIAP) has been classically identified as a cell death regulator. Here, we demonstrate a novel function of XIAP as a regulator of neurite outgrowth in neuronal ...