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Sensing of nutrients by CPT1C controls SAC1 activity to regulate AMPA receptor trafficking
(Journal of Cell Biology, 2020)Carnitine palmitoyltransferase 1C (CPT1C) is a sensor of malonyl-CoA and is located in the ER of neurons. AMPA receptors (AMPARs) mediate fast excitatory neurotransmission in the brain and play a key ... -
Sensing of nutrients by CPT1C regulates late endosome/lysosome anterograde transport and axon growth
(eLife, 2019)Anterograde transport of late endosomes or lysosomes (LE/Lys) is crucial for proper axon growth. However, the role of energetic nutrients has been poorly explored. Malonyl-CoA is a precursor of fatty ... -
Serotype and clonal distribution dynamics of invasive pneumococcal strains after PCV13 introduction (2011-2016): surveillance data from 23 sites in Catalonia, Spain
(PLoS One, 2020-02)Background: The objective of this study is to describe incidence and shifts of serotype and clonal distribution of invasive Streptococcus pneumoniae strains in four different age groups (<5 years, 5–17 ... -
Serotype distribution of remaining pneumococcal meningitis in the mature PCV10/13 period: findings from the PSERENADE project
(Microorganisms, 2021)Pneumococcal conjugate vaccine (PCV) introduction has reduced pneumococcal meningitis incidence. The Pneumococcal Serotype Replacement and Distribution Estimation (PSERENADE) project described the ... -
Serotypes and clonal composition of streptococcus pneumoniae isolates causing IPD in children and adults in Catalonia before 2013 to 2015 and after 2017 to 2019 systematic introduction of PCV13
(Microbiology Spectrum, 2021)The goal of this study was to investigate the distribution of serotypes and clonal composition of Streptococcus pneumoniae isolates causing invasive pneumococcal disease (IPD) in Catalonia, before and ... -
Short-term effects of three types of hamstring stretching on length, neurodynamic response, and perceived sense of effort: a randomised cross-over trial
(Life, 2022)Background: Stretching techniques for hamstring muscles have been described both to increase muscle length and to evaluate nerve mechanosensitivity. Aim: We sought to evaluate the short-term effects of ... -
Signalling network of breast cancer cells in response to progesterone
(BioRxiv, 2020)Breast cancer cells enter into the cell cycle following progestin exposure by the activation of signalling cascades involving a plethora of enzymes, transcription factors and co-factors that transmit ... -
Silver deposition on titanium surface by electrochemical anodizing process reduces bacterial adhesion of Streptococcus sanguinis and Lactobacillus salivarius
(Clinical Oral Implants Research, 2014-05-30)Objectives: The aim of this study was to determine the antibacterial properties of silver‐doped titanium surfaces prepared with a novel electrochemical anodizing process. Material and methods: Titanium ... -
Simulation methods with extended stability for stiff biochemical Kinetics
(BMC Systems Biology, 2010)Background: With increasing computer power, simulating the dynamics of complex systems in chemistry and biology is becoming increasingly routine. The modelling of individual reactions in (bio)chemical ... -
SIREs: searching for iron-responsive elements
(Nucleic Acids Research, 2010-07)The iron regulatory protein/iron-responsive element regulatory system plays a crucial role in the post-transcriptional regulation of gene expression and its disruption results in human disease. IREs are ... -
SIRT1 regulates hepatic vldlr levels
(Cell Communication and Signaling, 2024)Background: Endoplasmic reticulum (ER) stress-mediated increases in the hepatic levels of the very low-density lipoprotein (VLDL) receptor (VLDLR) promote hepatic steatosis by increasing the delivery ... -
SIRT3 deficiency exacerbates fatty liver by attenuating the HIF1α-LIPIN 1 pathway and increasing CD36 through Nrf2
(Cell Communication and Signaling18;147, 2020-09-10)Background: Deficiency of mitochondrial sirtuin 3 (SIRT3), a NAD+-dependent protein deacetylase that maintains redox status and lipid homeostasis, contributes to hepatic steatosis. In this study, we ... -
Síndrome de muerte súbita del lactante: ¿siguen las familias las recomendaciones?
(Anales de Pediatría, 2020-04)Introducción: La postura en decúbito prono al dormir es el principal factor de riesgo modificable conocido para el síndrome de muerte súbita del lactante (SMSL). Existen otras recomendaciones respecto ... -
Skin cancer classification via convolutional neural networks: systematic review of studies involving human experts
(European Journal of Cancer, 2021-10)Background: Multiple studies have compared the performance of artificial intelligence (AI)–based models for automated skin cancer classification to human experts, thus setting the cornerstone for a ... -
Smartphone and tablet usage during COVID-19 pandemic confinement in children under 48 months in Barcelona (Spain)
(Healthcare, 2021)Background: Total lockdown due to COVID-19 pandemic might have potentially increased screen time in children. This study aims to describe the smartphone and tablets usage in children under 48 months ... -
A social return on investment analysis of improving the management of chronic obstructive pulmonary disease within the spanish national healthcare system
(International Journal of Chronic Obstructive Pulmonary Disease, 2022)Purpose: To define a set of proposals that would improve the current management of chronic obstructive pulmonary disease (COPD) within the Spanish National Healthcare System (SNHS) from a comprehensive ... -
Socio-economic and psychological impact of COVID-19 pandemic in a Spanish cohort BIOVAL-D-COVID-19 study protocol
(Gaceta Sanitaria, 2021)Objective: SARS-CoV-2 outbreak has a negative psychological impact among general population. Data comparing mental health status before and during the outbreak is needed. The BIOVAL-D-COVID-19 study ... -
Socio-environmental correlates of physical activity in patients with chronic obstructive pulmonary disease (COPD)
(Thorax, 2017)Background. Study of the causes of the reduced levels of physical activity in patients with COPD has been scarce and limited to biological factors. Aim: To assess the relationship between novel ... -
Soemmerring's rings developed around IOLs, in human donor eyes, can present internal transparent areas
(International Journal of Molecular Sciences, 2022)Soemmerring’s rings consist of a ring of lens epithelial derived cells that grow along the periphery of an aphakic lens capsule, or around an intraocular lens. These rings when visualized frontally, ... -
Soluble oligomers of amyloid-β peptide disrupt Membrane trafficking of α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor contributing to early synapse dysfunction
(Journal of Biological Chemistry, 2011-08-05)β-Amyloid (Aβ), a peptide generated from the amyloid precursor protein, is widely believed to underlie the pathophysiology of Alzheimer disease (AD). Emerging evidences suggest that soluble Aβ oligomers ...