Browsing Ciències de la Salut by Author "Villarroya, Francesc"

Now showing items 1-3 of 3

    • Hypothalamic AMPK-ER Stress-JNK1 axis mediates the central actions of thyroid hormones on energy balance 

      Martinez-Sanchez, Noelia; Seoane-Collazo, Patricia; Contreras, Cristina; Varela, Luis; Villarroya, Joan; Rial-Pensado, Eva; Buque, Xabier; Aurrekoetxea, Igor; Delgado, Teresa C.; Vazquez-Martinez, Rafael; Gonzalez-Garcia, Ismael; Roa, Juan; Whittle, Andrew J.; Gomez-Santos, Beatriz; Velagapudi, Vidya; Loraine Tung, Y. C.; Morgan, Donald A.; Voshol, Peter J.; Martinez de Morentin, Pablo B.; Lopez-Gonzalez, Tania; Linares-Pose, Laura; Gonzalez, Francisco; Chatterjee, Krishna; Sobrino, Tomas; Medina-Gomez, Gema; Davis, Roger J.; Casals i Farré, Núria; Oresic, Matej; Coll, Anthony P.; Vidal-Puig, Antonio; Mittag, Jens; Tena-Sempere, Manuel; Malagon, Maria M.; Dieguez, Carlos; Martinez-Chantar, Maria Luz; Aspichueta, Patricia; Rahmouni, Kamal; Nogueiras, Rubén; Sabio, Guadalupe; Villarroya, Francesc; Lopez, Miguel (Cell Metabolism, 2017-07)
      Thyroid hormones (THs) act in the brain to modulate energy balance. We show that central triiodothyronine (T3) regulates de novo lipogenesis in liver and lipid oxidation in brown adipose tissue (BAT) ...

    • SIRT1 regulates hepatic vldlr levels 

      Peyman, Mona; Babin-Ebell, Anna; Rodríguez Rodríguez, Rosalía; Rigon, Matilde; Aguilar-Recarte, David; Villarroya, Joan; Planavila, Anna; Villarroya, Francesc; Palomer, Xavier; Barroso, Emma; Vázquez-Carrera, Manuel (Cell Communication and Signaling, 2024)
      Background: Endoplasmic reticulum (ER) stress-mediated increases in the hepatic levels of the very low-density lipoprotein (VLDL) receptor (VLDLR) promote hepatic steatosis by increasing the delivery ...

    • SIRT3 deficiency exacerbates fatty liver by attenuating the HIF1α-LIPIN 1 pathway and increasing CD36 through Nrf2 

      Barroso, Emma; Rodríguez-Rodríguez, Rosalía; Zarei, Mohammad; Pizarro-Delgado, Javier; Planavila, Anna; Palomer, Xavier; Villarroya, Francesc; Vázquez-Carrera, Manuel (Cell Communication and Signaling18;147, 2020-09-10)
      Background: Deficiency of mitochondrial sirtuin 3 (SIRT3), a NAD+-dependent protein deacetylase that maintains redox status and lipid homeostasis, contributes to hepatic steatosis. In this study, we ...