Browsing Ciències de la Salut by Author "Villà-Freixa, Jordi"

Now showing items 1-8 of 8

    • A truncated form of IKKa is responsible for specific nuclear IKK activity in colorectal cancer 

      Margalef, Pol; Fernández-Majada, Vanessa; Villanueva, Alberto; Garcia-Carbonell, Ricard; Iglesias, Mar; López, Laura; Martínez-Iniesta, María; Villà-Freixa, Jordi; Mulero, Mari Carmen; Andreu, Montserrat; Torres, Ferran; Mayo, Marty W.; Bigas, Anna; Espinosa, Lluis (Cell Reports, 2012-10-25)
      Nuclear IKKα regulates gene transcription by phosphorylating specific substrates and has been linked to cancer progression and metastasis. However, the mechanistic connection between tumorigenesis and ...

    • Antiretroviral therapy suppressed participants withlow CD4RT-cell counts segregate according toopposite immunological phenotypes 

      Pérez-Santiago, Josué; Ouchi, Dan; Urrea, Victor; Carrillo, Jorge; Cabrera, Cecilia; Villà-Freixa, Jordi; Puig, Jordi; Paredes, Roger; Negredo, Eugènia; Clotet, Bonaventura; Massanella, Marta; Blanco, Julià (AIDS, 2016-09)
      Background:The failure to increase CD4þT-cell counts in some antiretroviral therapysuppressed participants (immunodiscordance) has been related to perturbed CD4þT-cell homeostasis and impacts clinical ...

    • CDK6 is activated by the atypical cyclin I to promote E2F-mediated gene expression and cancer cell proliferation 

      Quandt, Eva; Masip, Núria; Hernández-Ortega, Sara; Sánchez-Botet, Abril; Gasa, Laura; Fernández-Elorduy, Ainhoa; Plutta, Sara; Martínez-Láinez, Joan Marc; Bru, Samuel; Munoz-Torres, Pau M.; Floor, Martin; Villà-Freixa, Jordi; Morris, May C.; Vidal, August; Villanueva, Alberto; Clotet, Josep; Ribeiro, Mariana P. C. (Molecular Oncology, 2023)
      Cyclin-dependent kinases (CDKs), together with their cyclin partners, are the master cell cycle regulators. Remarkably, the cyclin family was extended to include atypical cyclins, characterized by ...

    • CDK6 is activated by the atypical cyclin I to promote E2F-mediated gene expression and cancer cell proliferation 

      Quandt Herrera, Eva; Masip Sales, Núria; Hernández Ortega, Sara; Sánchez‑Botet, Abril; Gasa, Laura; Fernández-Elorduy, Ainhoa; Plutta, Sara; Martínez Láinez, Joan Marc; Bru Rullo, Samuel; Munoz-Torres, Pau M.; Floor, Martin; Villà-Freixa, Jordi; Morris, May C.; Vidal, August; Villanueva, Alberto; Clotet, Josep; Ribeiro, Mariana (Molecular Oncology, 2023)
      Cyclin-dependent kinases (CDKs), together with their cyclin partners, are the master cell cycle regulators. Remarkably, the cyclin family was extended to include atypical cyclins, characterized by ...

    • Knowledge management for systems biology a general and visually driven framework applied to translational medicine 

      Maier, Dieter; Kalus, Wenzel; Wolff, Martin; Kalko, Susana G.; Roca, Josep; Marin de Mas, Igor; Turan, Nil; Cascante, Marta; Falciani, Francesco; Hernandez, Miguel; Villà-Freixa, Jordi; Losko, Sascha (BMC Systems Biology, 2011)
      Background: To enhance our understanding of complex biological systems like diseases we need to put all of the available data into context and use this to detect relations, pattern and rules which allow ...

    • New mutations in HFE2 and TFR2 genes causing non HFE-related hereditary hemochromatosis 

      Hernández, Gonzalo; Ferrer-Cortès, Xenia; Venturi, Veronica; Musri, Melina; Floor Pilquil, Martin; Muñoz Torres, Pau Marc; Hernandez Rodríguez, Ines; Ruiz Mínguez, Maria Àngels; Kelleher, Nicholas J.; Pelucchi, Sara; Piperno, Alberto; Plensa Alberca, Esther; Gener Ricós, Georgina; Cañamero Giró, Eloi; Pérez-Montero, Santiago; Tornador, Cristian; Villà-Freixa, Jordi; Sánchez, Mayka (Genes, 2021)
      Hereditary hemochromatosis (HH) is an iron metabolism disease clinically characterized by excessive iron deposition in parenchymal organs such as liver, heart, pancreas, and joints. It is caused by ...

    • Proteoliposomal formulations of an HIV-1 gp41-based miniprotein elicit a lipid-dependent immunodominant response overlapping the 2F5 binding motif 

      Molinos-Albert, Luis M.; Bilbao, Eneritz; Agulló, Luis; Marfil, Silvia; García, Elisabet; Rodríguez de la Concepción, Maria Luisa; Izquierdo-Useros, Nuria; Vilaplana, Cristina; Nieto-Garai, Jon A.; Contreras, F. Xabier; Floor, Martin; Cardona, Pere J.; Martinez-Picado, Javier; Clotet, Bonaventura; Villà-Freixa, Jordi; Lorizate, Maier; Carrillo, Jorge; Blanco, Julià (Scientific Reports, 2017-01-13)

    • Simulation methods with extended stability for stiff biochemical Kinetics 

      Rué, Pau; Villà-Freixa, Jordi; Burrage, Kevin (BMC Systems Biology, 2010)
      Background: With increasing computer power, simulating the dynamics of complex systems in chemistry and biology is becoming increasingly routine. The modelling of individual reactions in (bio)chemical ...