Browsing Ciències de la Salut by Author "Hentze, Matthias W."
Now showing items 1-7 of 7
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An Hfe-dependent pathway mediates hyposideremia in response to lipopolysaccharide-induced inflammation in mice
Roy, Cindy N.; Custodio, Angel O.; de Graaf, Jos; Schneider, Susanne; Akpan, Imo; Montross, Lynne K.; Sanchez, Mayka; Gaudino, Alessandro; Hentze, Matthias W.; Andrews, Nancy C.; Muckenthaler, Martina U. (Nature Genetics, 2004)Inflammation influences iron balance in the whole organism. A common clinical manifestation of these changes is anemia of chronic disease (ACD; also called anemia of inflammation). Inflammation reduces ... -
Identification of target mRNAs of regulatory RNA-binding proteins using mRNP immunopurification and microarrays
Sanchez, Mayka; Galy, Bruno; Hentze, Matthias W.; Muckenthaler, Martina U. (Nature Protocols, 2007)RNA-binding proteins (RBPs) frequently regulate the post-transcriptional fate of target mRNAs. To identify novel target mRNAs of RBPs, we incubate total RNA with recombinant RBP and immunoselect the ... -
Iron regulatory protein-1 and -2: transcriptome-wide definition of binding mRNAs and shaping of the cellular proteome by iron regulatory proteins
Sanchez, Mayka; Galy, Bruno; Schwanhaeusser, Bjoern; Blake, Jonathon; Bähr-Ivacevic, Tomi; Benes, Vladimir; Selbach, Matthias; Muckenthaler, Martina U.; Hentze, Matthias W. (Blood, 2011)Iron regulatory proteins (IRPs) 1 and 2 are RNA-binding proteins that control cellular iron metabolism by binding to conserved RNA motifs called iron-responsive elements (IREs). The currently known ... -
Iron-regulatory proteins limit hypoxia-inducible factor 2α expression in iron deficiency
Sanchez, Mayka; Galy, Bruno; Muckenthaler, Martina U.; Hentze, Matthias W. (Nature Structural & Molecular Biology, 2007)Hypoxia stimulates erythropoiesis, the major iron-utilization pathway. We report the discovery of a conserved, functional iron-responsive element (IRE) in the 5′ untranslated region of the messenger RNA ... -
Is congenital secondary erythrocytosis/polycythemia caused by activating mutations within the HIF-2α iron-responsive element?
Percy, Melanie J.; Sanchez, Mayka; Swierczek, Sabina; McMullin, Mary Frances; Mojica-Henshaw, Mariluz P.; Muckenthaler, Martina U.; Prchal, Josef T.; Hentze, Matthias W. (Blood, 2007) -
SIREs: searching for iron-responsive elements
Campillos, Monica; Cases, Ildefonso; Hentze, Matthias W.; Sanchez, Mayka (Nucleic Acids Research, 2010-07)The iron regulatory protein/iron-responsive element regulatory system plays a crucial role in the post-transcriptional regulation of gene expression and its disruption results in human disease. IREs are ... -
The actin binding protein profilin 2 is a novel regulator of iron homeostasis
Luscieti, Sara; Galy, Bruno; Gutierrez, Lucia; Reinke, Michael; Couso, Jorge; Shvartsman, Maya; Di Pascale, Antonio; Witke, Walter; Hentze, Matthias W.; Pilo Boyl, Pietro; Sanchez, Mayka (Blood, 2017)Cellular iron homeostasis is controlled by the iron regulatory proteins (IRPs) 1 and 2 that bind cis-regulatory iron-responsive elements (IRE) on target messenger RNAs (mRNA). We identified profilin 2 ...