Visualitzant Ciències de la Salut per autor/a "Aldea Malo, Martí"
Ara mostrant els elements 1-7 de 7
-
Centromeric signaling proteins boost G1 cyclin degradation and modulate cell size in budding yeast
Martínez-Láinez, Joan M.; Moreno, David F.; Parisi, Eva; Clotet Erra, Josep; Aldea Malo, Martí (PLoS Biology, 2018-08-06)Cell size scales with ploidy in a great range of eukaryotes, but the underlying mechanisms remain unknown. Using various orthogonal single-cell approaches, we show that cell size increases linearly ... -
Competition in the chaperone-client network subordinates cell-cycle entry to growth and stress
Moreno, David F.; Parisi, Eva; Yahya, Galal; Vaggi, Federico; Csikász-Nagy, Attila; Aldea Malo, Martí (Life Science Alliance, 2019-04-15)The precise coordination of growth and proliferation has a universal prevalence in cell homeostasis. As a prominent property, cell size is modulated by the coordination between these processes in ... -
Growth rate as a direct regulator of the start network to set cell size
Aldea Malo, Martí; Jenkins, Kirsten; Csikász-Nagy, Attila (Frontiers in Cell and Developmental Biology, 2017-05-26)Cells are able to adjust their growth and size to external inputs to comply with specific fates and developmental programs. Molecular pathways controlling growth also have an enormous impact in cell ... -
Nucleosome architecture throughout the cell cycle
Deniz, Özgen; Flores, Óscar; Aldea Malo, Martí; Soler-López, Montserrat; Orozco, Modesto (Scientific Reports, 2016-01-28)Nucleosomes provide additional regulatory mechanisms to transcription and DNA replication by mediating the access of proteins to DNA. During the cell cycle chromatin undergoes several conformational ... -
Proteostasis collapse, a hallmark of aging, hinders the chaperone-Start network and arrests cells in G1
Moreno, David F.; Jenkins, Kirsten; Morlot, Sandrine; Charvin, Gilles; Csikász-Nagy, Attila; Aldea Malo, Martí (eLife, 2019-09-13)Loss of proteostasis and cellular senescence are key hallmarks of aging, but direct cause-effect relationships are not well understood. We show that most yeast cells arrest in G1 before death with low ... -
The critical size is set at a single-cell level by growth rate to attain homeostasis and adaptation
Ferrezuelo, Francisco; Colomina, Neus; Palmisano, Alida; Garí, Eloi; Gallego, Carme; Csikász-Nagy, Attila; Aldea Malo, Martí (Nature Communications, 2012-08-21)Budding yeast cells are assumed to trigger Start and enter the cell cycle only after they attain a critical size set by external conditions. However, arguing against deterministic models of cell size ... -
The transcriptional network activated by Cln3 cyclin at the G1-to-S transition of the yeast cell cycle
Ferrezuelo, Francisco; Colomina, Neus; Futcher, Bruce; Aldea Malo, Martí (Genome Biology, 2010-06-23)Background: The G1-to-S transition of the cell cycle in the yeast Saccharomyces cerevisiae involves an extensive transcriptional program driven by transcription factors SBF (Swi4-Swi6) and MBF (Mbp1-Swi6). ...