Installing multifunctionality on titanium with RGD-decorated polyurethane-polyurea roxithromycin loaded nanoparticles: toward new osseointegrative therapies

A novel class of polyurethane-polyurea nanoparticles (PUUa NPs) to install multifunctionality on biomaterials is presented. Biofunctionalization of titanium with roxithromycin loaded RGD-decorated PUUa NPs results in an outstanding improvement of osteoblast adhesion and strong suppression of bacterial attachment. This strategy represents a powerful approach to enhance the osseointegration of implant materials.

Document Type

Article

Document version

Accepted version

Language

English

Subject (CDU)

61 - Medical sciences

Keywords

Titani

Materials biomèdics

Implants

Materials nanoestructurats

Pèptids

Titanio

Materiales biomédicos

Implantes

Materiales nanoestructurados

Nanostructured materials

Peptides

Publisher

Wiley

Collection

4; 13

Is part of

Advanced Healthcare Materials

Recommended citation

Rocas, Pau; Hoyos Nogués, Mireia; Rocas, Josep [et al.]. Installing multifunctionality on titanium with RGD-decorated polyurethane-polyurea roxithromycin loaded nanoparticles: toward new osseointegrative therapies. Advanced Healthcare Materials, 2015, 4(13), p. 1-5. Disponible en: <https://onlinelibrary.wiley.com/doi/full/10.1002/adhm.201500245>. Fecha de acceso: 17 jun. 2020. DOI: 10.1002/adhm.201500245

Grant agreement number

info:eu-repo/grantAgreement/ES/MINECO/6PN/MAT2012-30706

info:eu-repo/grantAgreement/EC/FP7/321985

Note

The authors thank the Spanish Government for financial support through Project No. MAT2012–30706, cofunded by the European Union through European Regional Development Funds, and the Government of Catalonia (SGR2009 1039). C.M.-M. thanks the support of the Secretary for Universities and Research of the Ministry of Economy and Knowledge of the Government of Catalonia (2011-BP-B-00042) and the People Programme (Marie Curie Actions) of the European Union’s Seventh Framework Programme (FP7-PEOPLE-2012-CIG, REA Grant Agreement No. 321985). P.R., J.R., and F.A. thank the Spanish Government (MICINN) for fi nancial support into the INNPACTO Project No. IPT-090000–2010–1 (Polysfera).

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Ciències de la Salut [980]

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