Installing multifunctionality on titanium with RGD-decorated polyurethane-polyurea roxithromycin loaded nanoparticles: toward new osseointegrative therapies

A novel class of polyurethane-polyurea nanoparticles (PUUa NPs) to install multifunctionality on biomaterials is presented. Biofunctionalization of titanium with roxithromycin loaded RGD-decorated PUUa NPs results in an outstanding improvement of osteoblast adhesion and strong suppression of bacterial attachment. This strategy represents a powerful approach to enhance the osseointegration of implant materials.

Tipus de document

Article

Versió del document

Versió acceptada

Llengua

Anglès

Matèries (CDU)

61 - Medicina

Paraules clau

Titani

Materials biomèdics

Implants

Materials nanoestructurats

Pèptids

Titanio

Materiales biomédicos

Implantes

Materiales nanoestructurados

Nanostructured materials

Peptides

Pàgines

Publicat per

Wiley

Col·lecció

4; 13

Publicat a

Advanced Healthcare Materials

Citació recomanada

Rocas, Pau; Hoyos Nogués, Mireia; Rocas, Josep [et al.]. Installing multifunctionality on titanium with RGD-decorated polyurethane-polyurea roxithromycin loaded nanoparticles: toward new osseointegrative therapies. Advanced Healthcare Materials, 2015, 4(13), p. 1-5. Disponible en: <https://onlinelibrary.wiley.com/doi/full/10.1002/adhm.201500245>. Fecha de acceso: 17 jun. 2020. DOI: 10.1002/adhm.201500245

Número de l'acord de la subvenció

info:eu-repo/grantAgreement/ES/MINECO/6PN/MAT2012-30706

info:eu-repo/grantAgreement/EC/FP7/321985

Nota

The authors thank the Spanish Government for financial support through Project No. MAT2012–30706, cofunded by the European Union through European Regional Development Funds, and the Government of Catalonia (SGR2009 1039). C.M.-M. thanks the support of the Secretary for Universities and Research of the Ministry of Economy and Knowledge of the Government of Catalonia (2011-BP-B-00042) and the People Programme (Marie Curie Actions) of the European Union’s Seventh Framework Programme (FP7-PEOPLE-2012-CIG, REA Grant Agreement No. 321985). P.R., J.R., and F.A. thank the Spanish Government (MICINN) for fi nancial support into the INNPACTO Project No. IPT-090000–2010–1 (Polysfera).

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