Mostra el registre parcial de l'element
Two different strategies to enhance osseointegration in porous titanium: inorganic thermo-chemical treatment versus organic coating by peptide adsorption
dc.contributor.author | Ortiz-Hernández, Monica | |
dc.contributor.author | Rappe, Katrin S. | |
dc.contributor.author | Molmeneu, Meritxell | |
dc.contributor.author | Mas-Moruno, Carlos | |
dc.contributor.author | Guillem Martí, Jordi | |
dc.contributor.author | Punset fuste, Miquel | |
dc.contributor.author | CAPARROS, CRISTINA | |
dc.contributor.author | Calero, Jose | |
dc.contributor.author | franch, jordi | |
dc.contributor.author | Fernandez-Fairen, Mariano | |
dc.contributor.author | Gil Mur, Francisco Javier | |
dc.date.accessioned | 2020-05-30T14:14:11Z | |
dc.date.available | 2020-05-30T14:14:11Z | |
dc.date.issued | 2018 | |
dc.identifier.citation | Ortiz-Hernandez, Monica; Rappe, Katrin S.; Molmeneu, Meritxell. Two different strategies to enhance osseointegration in porous titanium: inorganic thermo-chemical treatment versus organic coating by peptide adsorption. International Journal of Molecular Sciences, 2018, 19(9), p. 1-17. Disponible en: <https://www.mdpi.com/1422-0067/19/9/2574>. Fecha de acceso: 30 may. 2020. DOI: 10.3390/ijms19092574. | ca |
dc.identifier.issn | 1422-0067 | ca |
dc.identifier.uri | http://hdl.handle.net/20.500.12328/1558 | |
dc.description.abstract | In this study, highly-interconnected porous titanium implants were produced by powder sintering with different porous diameters and open interconnectivity. The actual foams were produced using high cost technologies: Chemical Vapor Deposition (CVD), Physical Vapor Deposition (PVD), and spark plasma sintering, and the porosity and/or interconnection was not optimized. The aim was to generate a bioactive surface on foams using two different strategies, based on inorganic thermo-chemical treatment and organic coating by peptide adsorption, to enhance osseointegration. Porosity was produced using NaCl as a space holder and polyethyleneglicol as a binder phase. Static and fatigue tests were performed in order to determine mechanical behaviors. Surface bioactivation was performed using a thermo-chemical treatment or by chemical adsorption with peptides. Osteoblast-like cells were cultured and cytotoxicity was measured. Bioactivated scaffolds and a control were implanted in the tibiae of rabbits. Histomorphometric evaluation was performed at 4 weeks after implantation. Interconnected porosity was 53% with an average diameter of 210 µm and an elastic modulus of around 1 GPa with good mechanical properties. The samples presented cell survival values close to 100% of viability. Newly formed bone was observed inside macropores, through interconnected porosity, and on the implant surface. Successful bone colonization of inner structure (40%) suggested good osteoconductive capability of the implant. Bioactivated foams showed better results than non-treated ones, suggesting both bioactivation strategies induce osteointegration capability. | ca |
dc.format.extent | 17 | ca |
dc.language.iso | eng | ca |
dc.publisher | MDPI | ca |
dc.relation.ispartof | International Journal of Molecular Sciences | ca |
dc.relation.ispartofseries | 19;9 | |
dc.rights | © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open accessarticle distributed under the terms and conditions of the Creative Commons Attribution(CC BY) license (http://creativecommons.org/licenses/by/4.0/). | ca |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.subject.other | Implants dentals | ca |
dc.subject.other | Titani | |
dc.subject.other | Pèptids | |
dc.subject.other | Sal | |
dc.subject.other | Implantes dentales | |
dc.subject.other | Titanio | |
dc.subject.other | Péptidos | |
dc.subject.other | Sal | |
dc.subject.other | Dental implants | |
dc.subject.other | Titanium | |
dc.subject.other | Peptides | |
dc.subject.other | Sodium chloride | |
dc.title | Two different strategies to enhance osseointegration in porous titanium: inorganic thermo-chemical treatment versus organic coating by peptide adsorption | ca |
dc.type | info:eu-repo/semantics/article | ca |
dc.description.version | info:eu-repo/semantics/acceptedVersion | ca |
dc.embargo.terms | cap | ca |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO/MAT2015-67183-R | |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO/MAT2017-83905-R | |
dc.subject.udc | 616.3 | ca |
dc.identifier.doi | https://dx.doi.org/10.3390/ijms19092574 | ca |
Fitxers en aquest element
Aquest element apareix en la col·lecció o col·leccions següent(s)
-
Odontologia [245]