Two different strategies to enhance osseointegration in porous titanium: inorganic thermo-chemical treatment versus organic coating by peptide adsorption
Author
Ortiz-Hernández, Monica
Rappe, Katrin S.
Mas-Moruno, Carlos
Guillem Martí, Jordi
CAPARROS, CRISTINA
Calero, Jose
franch, jordi
Fernandez-Fairen, Mariano
Gil Mur, Francisco Javier
Publication date
2018ISSN
1422-0067
Abstract
In this study, highly-interconnected porous titanium implants were produced by powder sintering with different porous diameters and open interconnectivity. The actual foams were produced using high cost technologies: Chemical Vapor Deposition (CVD), Physical Vapor Deposition (PVD), and spark plasma sintering, and the porosity and/or interconnection was not optimized. The aim was to generate a bioactive surface on foams using two different strategies, based on inorganic thermo-chemical treatment and organic coating by peptide adsorption, to enhance osseointegration. Porosity was produced using NaCl as a space holder and polyethyleneglicol as a binder phase. Static and fatigue tests were performed in order to determine mechanical behaviors. Surface bioactivation was performed using a thermo-chemical treatment or by chemical adsorption with peptides. Osteoblast-like cells were cultured and cytotoxicity was measured. Bioactivated scaffolds and a control were implanted in the tibiae of rabbits. Histomorphometric evaluation was performed at 4 weeks after implantation. Interconnected porosity was 53% with an average diameter of 210 µm and an elastic modulus of around 1 GPa with good mechanical properties. The samples presented cell survival values close to 100% of viability. Newly formed bone was observed inside macropores, through interconnected porosity, and on the implant surface. Successful bone colonization of inner structure (40%) suggested good osteoconductive capability of the implant. Bioactivated foams showed better results than non-treated ones, suggesting both bioactivation strategies induce osteointegration capability.
Document Type
Article
Document version
Accepted version
Language
English
Subject (CDU)
616.3 - Pathology of the digestive system. Complaints of the alimentary canal
Keywords
Implants dentals
Titani
Pèptids
Sal
Implantes dentales
Titanio
Péptidos
Sal
Dental implants
Titanium
Peptides
Sodium chloride
Pages
17
Publisher
MDPI
Collection
19; 9
Is part of
International Journal of Molecular Sciences
Citation
Ortiz-Hernandez, Monica; Rappe, Katrin S.; Molmeneu, Meritxell. Two different strategies to enhance osseointegration in porous titanium: inorganic thermo-chemical treatment versus organic coating by peptide adsorption. International Journal of Molecular Sciences, 2018, 19(9), p. 1-17. Disponible en: <https://www.mdpi.com/1422-0067/19/9/2574>. Fecha de acceso: 30 may. 2020. DOI: 10.3390/ijms19092574.
Grant agreement number
info:eu-repo/grantAgreement/MINECO/MAT2015-67183-R
info:eu-repo/grantAgreement/MINECO/MAT2017-83905-R
This item appears in the following Collection(s)
- Odontologia [245]
Rights
© 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open accessarticle distributed under the terms and conditions of the Creative Commons Attribution(CC BY) license (http://creativecommons.org/licenses/by/4.0/).
Except where otherwise noted, this item's license is described as https://creativecommons.org/licenses/by/4.0/