Two different strategies to enhance osseointegration in porous titanium: inorganic thermo-chemical treatment versus organic coating by peptide adsorption
Autor/a
Ortiz-Hernández, Monica
Rappe, Katrin S.
Molmeneu, Meritxell
Mas-Moruno, Carlos
Guillem Martí, Jordi
Punset fuste, Miquel
CAPARROS, CRISTINA
Calero, Jose
franch, jordi
Fernandez-Fairen, Mariano
Gil Mur, Francisco Javier
Fecha de publicación
2018ISSN
1422-0067
Resumen
In this study, highly-interconnected porous titanium implants were produced by powder sintering with different porous diameters and open interconnectivity. The actual foams were produced using high cost technologies: Chemical Vapor Deposition (CVD), Physical Vapor Deposition (PVD), and spark plasma sintering, and the porosity and/or interconnection was not optimized. The aim was to generate a bioactive surface on foams using two different strategies, based on inorganic thermo-chemical treatment and organic coating by peptide adsorption, to enhance osseointegration. Porosity was produced using NaCl as a space holder and polyethyleneglicol as a binder phase. Static and fatigue tests were performed in order to determine mechanical behaviors. Surface bioactivation was performed using a thermo-chemical treatment or by chemical adsorption with peptides. Osteoblast-like cells were cultured and cytotoxicity was measured. Bioactivated scaffolds and a control were implanted in the tibiae of rabbits. Histomorphometric evaluation was performed at 4 weeks after implantation. Interconnected porosity was 53% with an average diameter of 210 µm and an elastic modulus of around 1 GPa with good mechanical properties. The samples presented cell survival values close to 100% of viability. Newly formed bone was observed inside macropores, through interconnected porosity, and on the implant surface. Successful bone colonization of inner structure (40%) suggested good osteoconductive capability of the implant. Bioactivated foams showed better results than non-treated ones, suggesting both bioactivation strategies induce osteointegration capability.
Tipo de documento
Artículo
Versión del documento
Versión aceptada
Lengua
Inglés
Materias (CDU)
616.3 - Patología del aparato digestivo. Odontología
Palabras clave
Implants dentals
Titani
Pèptids
Sal
Implantes dentales
Titanio
Péptidos
Sal
Dental implants
Titanium
Peptides
Sodium chloride
Páginas
17
Publicado por
MDPI
Colección
19;9
Publicado en
International Journal of Molecular Sciences
Citación
Ortiz-Hernandez, Monica; Rappe, Katrin S.; Molmeneu, Meritxell. Two different strategies to enhance osseointegration in porous titanium: inorganic thermo-chemical treatment versus organic coating by peptide adsorption. International Journal of Molecular Sciences, 2018, 19(9), p. 1-17. Disponible en: <https://www.mdpi.com/1422-0067/19/9/2574>. Fecha de acceso: 30 may. 2020. DOI: 10.3390/ijms19092574.
Número del acuerdo de la subvención
info:eu-repo/grantAgreement/MINECO/MAT2015-67183-R
info:eu-repo/grantAgreement/MINECO/MAT2017-83905-R
Este ítem aparece en la(s) siguiente(s) colección(ones)
- Odontologia [226]
Derechos
© 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open accessarticle distributed under the terms and conditions of the Creative Commons Attribution(CC BY) license (http://creativecommons.org/licenses/by/4.0/).
Excepto si se señala otra cosa, la licencia del ítem se describe como https://creativecommons.org/licenses/by/4.0/