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dc.contributor.authorOrtiz-Hernandez, Monica
dc.contributor.authorRappe, Katrin S.
dc.contributor.authorMolmeneu, Meritxell
dc.contributor.authorMas-Moruno, Carles
dc.contributor.authorGuillem-Marti, Jordi
dc.contributor.authorPunset, Miquel
dc.contributor.authorCaparros, Cristina
dc.contributor.authorCalero, Jose
dc.contributor.authorFranch, Jordi
dc.contributor.authorFernandez-Fairen, Mariano
dc.contributor.authorGil Mur, Francisco Javier
dc.date.accessioned2020-05-30T14:14:11Z
dc.date.available2020-05-30T14:14:11Z
dc.date.issued2018
dc.identifier.citationOrtiz-Hernandez, Monica; Rappe, Katrin S.; Molmeneu, Meritxell. Two different strategies to enhance osseointegration in porous titanium: inorganic thermo-chemical treatment versus organic coating by peptide adsorption. International Journal of Molecular Sciences, 2018, 19(9), p. 1-17. Disponible en: <https://www.mdpi.com/1422-0067/19/9/2574>. Fecha de acceso: 30 may. 2020. DOI: 10.3390/ijms19092574.ca
dc.identifier.issn1422-0067ca
dc.identifier.urihttp://hdl.handle.net/20.500.12328/1558
dc.description.abstractIn this study, highly-interconnected porous titanium implants were produced by powder sintering with different porous diameters and open interconnectivity. The actual foams were produced using high cost technologies: Chemical Vapor Deposition (CVD), Physical Vapor Deposition (PVD), and spark plasma sintering, and the porosity and/or interconnection was not optimized. The aim was to generate a bioactive surface on foams using two different strategies, based on inorganic thermo-chemical treatment and organic coating by peptide adsorption, to enhance osseointegration. Porosity was produced using NaCl as a space holder and polyethyleneglicol as a binder phase. Static and fatigue tests were performed in order to determine mechanical behaviors. Surface bioactivation was performed using a thermo-chemical treatment or by chemical adsorption with peptides. Osteoblast-like cells were cultured and cytotoxicity was measured. Bioactivated scaffolds and a control were implanted in the tibiae of rabbits. Histomorphometric evaluation was performed at 4 weeks after implantation. Interconnected porosity was 53% with an average diameter of 210 µm and an elastic modulus of around 1 GPa with good mechanical properties. The samples presented cell survival values close to 100% of viability. Newly formed bone was observed inside macropores, through interconnected porosity, and on the implant surface. Successful bone colonization of inner structure (40%) suggested good osteoconductive capability of the implant. Bioactivated foams showed better results than non-treated ones, suggesting both bioactivation strategies induce osteointegration capability.ca
dc.format.extent17ca
dc.language.isoengca
dc.publisherMDPIca
dc.relation.ispartofInternational Journal of Molecular Sciencesca
dc.relation.ispartofseries19;9
dc.rights© 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open accessarticle distributed under the terms and conditions of the Creative Commons Attribution(CC BY) license (http://creativecommons.org/licenses/by/4.0/).ca
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subject.otherImplants dentalsca
dc.subject.otherTitani
dc.subject.otherPèptids
dc.subject.otherSal
dc.subject.otherImplantes dentales
dc.subject.otherTitanio
dc.subject.otherPéptidos
dc.subject.otherSal
dc.subject.otherDental implants
dc.subject.otherTitanium
dc.subject.otherPeptides
dc.subject.otherSodium chloride
dc.titleTwo different strategies to enhance osseointegration in porous titanium: inorganic thermo-chemical treatment versus organic coating by peptide adsorptionca
dc.typeinfo:eu-repo/semantics/articleca
dc.description.versioninfo:eu-repo/semantics/acceptedVersionca
dc.embargo.termscapca
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/MINECO/2PE/MAT2017-83905-Rca
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/MINECO/2PE/MAT2015-67183-Rca
dc.subject.udc616.3ca
dc.identifier.doihttps://dx.doi.org/10.3390/ijms19092574ca


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© 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open accessarticle distributed under the terms and conditions of the Creative Commons Attribution(CC BY) license (http://creativecommons.org/licenses/by/4.0/).
Except where otherwise noted, this item's license is described as https://creativecommons.org/licenses/by/4.0/