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Differential HMG‐CoA lyase expression in human tissues provides clues about 3‐hydroxy‐3‐methylglutaric aciduria
(Wiley, 2010)
3‐Hydroxy‐3‐methylglutaric aciduria is a rare human autosomal recessive disorder caused by deficiency of 3‐hydroxy‐3‐methylglutaryl CoA lyase (HL). This mitochondrial enzyme catalyzes the common final ...
The IronChip evaluation package: a package of perl modules for robust analysis of custom microarrays
(Springer Nature, 2010)
Background: Gene expression studies greatly contribute to our understanding of complex relationships in gene regulatory networks. However, the complexity of array design, production and manipulations ...
SIREs: searching for iron-responsive elements
(Oxford University Press, 2010-07)
The iron regulatory protein/iron-responsive element regulatory system plays a crucial role in the post-transcriptional regulation of gene expression and its disruption results in human disease. IREs are ...
Effectiveness of a Surgery Admission Unit for patients undergoing major elective surgery in a tertiary university hospital
(Springer Nature, 2010-01-22)
Background: The increasing demand on hospitalisation, either due to elective activity from the waiting lists or due to emergency admissions coming from the Emergency Department (ED), requires looking ...
The transcriptional network activated by Cln3 cyclin at the G1-to-S transition of the yeast cell cycle
(BMC, 2010-06-23)
Background: The G1-to-S transition of the cell cycle in the yeast Saccharomyces cerevisiae involves an extensive
transcriptional program driven by transcription factors SBF (Swi4-Swi6) and MBF (Mbp1-Swi6). ...
Simulation methods with extended stability for stiff biochemical Kinetics
(Springer Nature, 2010)
Background: With increasing computer power, simulating the dynamics of complex systems in chemistry and biology is becoming increasingly routine. The modelling of individual reactions in (bio)chemical ...