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CPT1c in specific hypothalamic nuclei and its role in lipid sensing and metabolic adaptation
(Universitat Internacional de Catalunya, 2022-09-23)
Obesity has become a pandemic disease in the last 40 years. The WHO estimates that the
population with overweight has nearly tripled since 1975, and the tendency is still growing.
These data have an ...
Microglial stress pathways triggered by graphene nanomaterials and amyloid-beta: from silent activation to overactivation at the root of neurodegeneration
(Universitat Internacional de Catalunya, 2026-03-03)
La microglia és la sentinella immunitària innata del sistema nerviós central, responsable de descodificar els senyals extracel·lulars i coordinar les respostes neuroinflamatòries. Més enllà de les vies ...
CPT1C-ABHD6 interaction in hypothalamic neurons: implications for bis (monoacylglycero) phosphate metabolism and the endolysosomal system
(Universitat Internacional de Catalunya, 2024-02-14)
El sistema endolisosomal juga un paper crític en la funció neuronal i ha emergit com a un potencial objectiu per al tractament de diverses malalties neuronals, com els trastorns neurodegeneratius i fins ...
Development of C75-CoA loaded polymeric micelles targeting brain CPT1A: A novel nanomedicine-based approach to fight obesity and cancer
(Universitat Internacional de Catalunya, 2024-02-14)
Brain lipid metabolism has a key role in many physiological processes, and its malfunction is associated with a plethora of diseases, such as obesity and glioblastoma multiforme (GBM). Carnitine palmitoyl ...
Papel de CPT1C en el desarrollo axonal y en el transporte de los endosomas tardíos
(Universitat Internacional de Catalunya, 2018-03-23)
La paraplejía espástica hereditaria agrupa un conjunto de desórdenes neurodegenerativos caracterizados por espasticidad y rigidez muscular. Todos ellos están relacionados clínica y patológicamente con ...
JNK3 signalling mediates sex-specific hypothalamic inflammation and microglial dynamics in the onset of insulin resistance following short-term high-fat diet
(Universitat Internacional de Catalunya, 2025-07-08)
L'obesitat és un problema creixent de salut pública, estretament vinculat a la inflamació crònica i a l'aparició de resistència a la insulina. El model d'obesitat induïda per una dieta rica en greixos ...
CPT1C-dependent regulation of GluA1 trafficking under metabolic stress
(Universitat Internacional de Catalunya, 2019-12-10)
Carnitine palmitoyltransferase 1C (CPT1C) is the brain-specific isoform of the CPT1 family which is located at the endoplasmic reticulum (ER) of neurons and exhibits low catalytic activity, but still ...
CPT1C and endocannabinoids as hypothalamic players in early stages of obesity development
(Universitat Internacional de Catalunya, 2019-12-10)
Obesity prevalence in worldwide population is increasing every day due to an imbalance between the energy intake and the energy expenditure. Rich-caloric food is highly palatable and easily accessible, ...