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Characterization of new mutations in transferrin, DMT1 and SEC23B causing rare iron metabolism-related diseases; and the discovery of RACGAP1 as the gene responsible for autosomal recessive congenital dyserythropoietic anaemia type III
(Universitat Internacional de Catalunya, 2023-11-25)
Iron is a biometal involved in many physiological processes that are essential for life. Iron metabolism is a complex and tightly regulated process both at the systemic and cellular level. Proper iron ...
Extracellular UTP signalling in Schwann cell migration: A novel role of the P2Y2 receptor
(Universitat Internacional de Catalunya, 2013-09-24)
Peripheral neuropaties are one of the major complications of the Peripheral Nervous System. Depsite the big importance of those pathologies, less drugs are effective for their treatment, and most of the ...
Role of CPT1C in breast cancer development and chemoresistance
(Universitat Internacional de Catalunya, 2021-07-14)
Carnitine palmitoyl transferase 1 (CPT1) are enzymes that catalyze the conversion of long-chain acyl-CoA to acyl-carnitines, to transport long-chain fatty acids across intracellular membranes. CPT1C ...
Evaluation of biomarkers for studying new challenges in tobacco control
(Universitat Internacional de Catalunya, 2023-12-19)
El tabaquismo es reconocido a nivel global como un factor de riesgo significativo para la salud pública y una
de las principales causas de muertes prevenibles. España ha implementado políticas de control ...
CPT1c in specific hypothalamic nuclei and its role in lipid sensing and metabolic adaptation
(Universitat Internacional de Catalunya, 2022-09-23)
Obesity has become a pandemic disease in the last 40 years. The WHO estimates that the
population with overweight has nearly tripled since 1975, and the tendency is still growing.
These data have an ...
Caracterización molecular de nuevos substratos de la CDK Pho85
(Universitat Internacional de Catalunya, 2013-07-29)
La ciclina Cln3 es un activador crítico de START, cuya sobreexpresión provoca células de menor tamaño que progresan rápidamente por el ciclo celular, mientras que su deleción induce un mayor tamaño de ...
Rol de CPT1C en la supervivencia de las células madre mesenquimales
(Universitat Internacional de Catalunya, 2016-09-06)
La carnitina palmitoiltransferasa 1C (CPT1C) pertenece a la familia de enzimas CPT1, las cuales controlan la entrada de ácidos grasos al lumen de la mitocondria para su posterior oxidación. Sin embargo, ...
Caracterización de complejos CDK-Ciclina atípicos humanos
(Universitat Internacional de Catalunya, 2018-03-15)
La desregulación en los mecanismos de control del ciclo celular es un evento indiscutiblemente asociado a la aparición de diversas patologías, entre las que destacan los procesos tumorales. Como principales ...
The role of forgiveness in disclosure and victim suport after a patient safety incident
(Universitat Internacional de Catalunya, 2022-01-26)
In the healthcare field, we know patient safety incidents are unfortunate events that occur. Two groups are affected by these incidents: Patients become first victims and the professionals involved turn ...
Evaluation of the impact of Spanish smoking legislation on tobacco consumption and passive exposure
(Universitat Internacional de Catalunya, 2018-03-14)
In Spain, two smoke-free laws have been passed after the approval of the FCTC. In 2005, it came into effect a smoke-free legislation (Law 28/2005). This law was a great advance for public health in ...