A novel Chilean salmon fish backbone-based nanoHydroxyApatite functional biomaterial for potential use in bone tissue engineering
Author
Muñoz, F.
Haidar, Z. S.
Guerra, I.
Padilla, M. Cristina
Ortega, N.
García, M. J.
Publication date
2024ISSN
2296-858X
Abstract
Introduction: Given the ensuing increase in bone and periodontal diseases and defects, de novo bone repair and/or regeneration strategies are constantly undergoing-development alongside advances in orthopedic, oro-dental and cranio-maxillo-facial technologies and improvements in bio−/nano-materials. Indeed, there is a remarkably growing need for new oro-dental functional biomaterials that can help recreate soft and hard tissues and restore function and aesthetics of teeth/ dentition and surrounding tissues. In bone tissue engineering, HydroxyApatite minerals (HAp), the most stable CaP/Calcium Phosphate bioceramic and a widely-used material as a bone graft substitute, have been extensively studied for regenerative medicine and dentistry applications, including clinical use. Yet, limitations and challenges owing principally to its bio-mechanical strength, exist and therefore, research and innovation efforts continue to pursue enhancing its bio-effects, particularly at the nano-scale. Methods: Herein, we report on the physico-chemical properties of a novel nanoHydroxyApatite material obtained from the backbone of Salmon fish (patent-pending); an abundant and promising yet under-explored alternative HAp source. Briefly, our nanoS-HAp obtained via a modified and innovative alkaline hydrolysis–calcination process was characterized by X-ray diffraction, electron microscopy, spectroscopy, and a cell viability assay. Results and Discussion: When compared to control HAp (synthetic, human, bovine or porcine), our nanoS-HAp demonstrated attractive characteristics, a promising biomaterial candidate for use in bone tissue engineering, and beyond.
Document Type
Article
Document version
Published version
Language
English
Subject (CDU)
616.3 - Pathology of the digestive system. Complaints of the alimentary canal
Keywords
Biomaterials
Hidroxiapatita
Nanotecnologia
Osteointegrativa
Osteoconducció
Ós de salmó
Bioenginyeria
Biomateriales
Hidroxiapatita
Nanotecnología
Osteointegrativa
Osteoconducción
Hueso de salmón
Bioingeniería
Biomaterials
Hydroxyapatite
Nanotechnology
Osteointegrative
Osteoconduction
Osteoinduction
Salmon bone
Bioengineering
Pages
10
Publisher
Frontiers Media
Collection
11
Is part of
Frontiers in Medicine
Citation
Muñoz, F.; Haidar, Z. S.; Puigdollers, Andreu [et al.]. A novel Chilean salmon fish backbone-based nanoHydroxyApatite functional biomaterial for potential use in bone tissue engineering. Frontiers in Medicine, 2024, 11, 1330482. Disponible en: <https://www.frontiersin.org/articles/10.3389/fmed.2024.1330482/full>. Fecha de acceso: 24 may. 2024. DOI: 10.3389/fmed.2024.1330482
This item appears in the following Collection(s)
- Odontologia [245]
Rights
© 2024 Muñoz, Haidar, Puigdollers, Guerra, Padilla, Ortega and García. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Except where otherwise noted, this item's license is described as https://creativecommons.org/licenses/by/4.0/