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Dynamic force spectroscopy of DNA hairpins: II. Irreversibility and dissipation
dc.contributor.author | Manosas, M. | |
dc.contributor.author | Mossa, A. | |
dc.contributor.author | Forns, N. | |
dc.contributor.author | Huguet Casades, Josep Maria | |
dc.contributor.author | Ritort, F. | |
dc.date.accessioned | 2024-03-18T15:13:18Z | |
dc.date.available | 2024-03-18T15:13:18Z | |
dc.date.issued | 2009 | |
dc.identifier.citation | Manosas, M.; Mossa, A.; Forns, N. [et al.]. Dynamic force spectroscopy of DNA hairpins: II. Irreversibility and dissipation. Journal of Statistical Mechanics: Theory and Experiment, 2009, 2009, P02061. Disponible en: <https://iopscience.iop.org/article/10.1088/1742-5468/2009/02/P02061/pdf>. Fecha de acceso: 18 mar. 2024. DOI: 10.1088/1742-5468/2009/02/P02061 | ca |
dc.identifier.issn | 1742-5468 | ca |
dc.identifier.uri | http://hdl.handle.net/20.500.12328/4170 | |
dc.description.abstract | We investigate irreversibility and dissipation in single molecules that cooperatively fold/unfold in a two-state manner under the action of mechanical force. We apply path thermodynamics to derive analytical expressions for the average dissipated work and the average hopping number in two-state systems. It is shown how these quantities only depend on two parameters that characterize the folding/unfolding kinetics of the molecule: the fragility and the coexistence hopping rate. The latter has to be rescaled to take into account the appropriate experimental set-up. Finally we carry out pulling experiments with optical tweezers in a specifically designed DNA hairpin that shows two-state cooperative folding. We then use these experimental results to validate our theoretical predictions. | ca |
dc.format.extent | Desconocido | ca |
dc.language.iso | eng | ca |
dc.publisher | IOP Publishing | ca |
dc.relation.ispartof | Journal of Statistical Mechanics: Theory and Experiment | ca |
dc.relation.ispartofseries | 2009 | |
dc.rights | © IOP Publishing | ca |
dc.subject.other | ADN | ca |
dc.subject.other | DNA | ca |
dc.title | Dynamic force spectroscopy of DNA hairpins: II. Irreversibility and dissipation | ca |
dc.type | info:eu-repo/semantics/article | ca |
dc.description.version | info:eu-repo/semantics/publishedVersion | ca |
dc.rights.accessLevel | info:eu-repo/semantics/openAccess | |
dc.embargo.terms | cap | ca |
dc.subject.udc | 57 | ca |
dc.identifier.doi | https://dx.doi.org/10.1088/1742-5468/2009/02/P02061 | ca |
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