dc.contributor.author | Huguet, Josep Maria | |
dc.contributor.author | Forns, N. | |
dc.contributor.author | Ritort, F. | |
dc.date.accessioned | 2024-03-18T13:51:22Z | |
dc.date.available | 2024-03-18T13:51:22Z | |
dc.date.issued | 2009 | |
dc.identifier.citation | Huguet, Josep Maria; Forns, N.; Ritort, F. Statistical Properties of Metastable Intermediates in DNA Unzipping. Physical Review Letters, 2009, 103, 248106. Disponible en: <https://journals.aps.org/prl/abstract/10.1103/PhysRevLett.103.248106>. Fecha de acceso: 18 mar. 2024. DOI: 10.1103/PhysRevLett.103.248106 | ca |
dc.identifier.issn | 0031-9007 | ca |
dc.identifier.uri | http://hdl.handle.net/20.500.12328/4165 | |
dc.description.abstract | We unzip DNA molecules using optical tweezers and determine the sizes of the cooperatively unzipping and zipping regions separating consecutive metastable intermediates along the unzipping pathway. Sizes are found to be distributed following a power law, ranging from one base pair up to more than a hundred base pairs. We find that a large fraction of unzipping regions smaller than 10 bp are seldom detected because of the high compliance of the released single stranded DNA. We show how the compliance of a single nucleotide sets a limit value around 0.1 N/m for the stiffness of any local force probe aiming to discriminate one base pair at a time in DNA unzipping experiments. | ca |
dc.format.extent | 4 | ca |
dc.language.iso | eng | ca |
dc.publisher | American Physical Society | ca |
dc.relation.ispartof | Physical Review Letters | ca |
dc.relation.ispartofseries | 103 | |
dc.rights | This article is available under the terms of the Creative Commons Attribution 3.0 License. Further distribution of this work must maintain attribution to the author(s) and the published article’s title, journal citation, and DOI. | ca |
dc.rights.uri | https://creativecommons.org/licenses/by/3.0/ | |
dc.subject.other | DNA | ca |
dc.title | Statistical properties of metastable intermediates in DNA unzipping | ca |
dc.type | info:eu-repo/semantics/article | ca |
dc.description.version | info:eu-repo/semantics/publishedVersion | ca |
dc.rights.accessLevel | info:eu-repo/semantics/openAccess | |
dc.embargo.terms | cap | ca |
dc.subject.udc | 57 | ca |
dc.identifier.doi | https://dx.doi.org/10.1103/PhysRevLett.103.248106 | ca |