dc.contributor.author | Chorostecki, Uciel | |
dc.contributor.author | Moro, Belen | |
dc.contributor.author | Rojas, Arantxa M.L. | |
dc.contributor.author | Debernardi, Juan M. | |
dc.contributor.author | Schapire, Arnaldo L. | |
dc.contributor.author | Notredame, Cedric | |
dc.contributor.author | Palatnik, Javier F. | |
dc.date.accessioned | 2024-02-07T14:18:53Z | |
dc.date.available | 2024-02-07T14:18:53Z | |
dc.date.issued | 2017 | |
dc.identifier.citation | Chorostecki, Uciel; Moro, Belen; Rojas, Arantxa M.L. [et al.]. Evolutionary footprints reveal insights into plant MicroRNA biogenesis. The Plant Cell, 2017, 29(6), p. 1248.1261. Disponible en: <https://academic.oup.com/plcell/article/29/6/1248/6099353?login=true>. Fecha de acceso: 7 feb. 2024. DOI: 10.1105/tpc.17.00272 | ca |
dc.identifier.issn | 1040-4651 | ca |
dc.identifier.uri | http://hdl.handle.net/20.500.12328/4043 | |
dc.description.abstract | MicroRNAs (miRNAs) are endogenous small RNAs that recognize target sequences by base complementarity and play a role in the regulation of target gene expression. They are processed from longer precursor molecules that harbor a fold-back structure. Plant miRNA precursors are quite variable in size and shape, and are recognized by the processing machinery in different ways. However, ancient miRNAs and their binding sites in target genes are conserved during evolution. Here, we designed a strategy to systematically analyze MIRNAs from different species generating a graphical representation of the conservation of the primary sequence and secondary structure. We found that plant MIRNAs have evolutionary footprints that go beyond the small RNA sequence itself, yet their location along the precursor depends on the specific MIRNA. We show that these conserved regions correspond to structural determinants recognized during the biogenesis of plant miRNAs. Furthermore, we found that the members of the miR166 family have unusual conservation patterns and demonstrated that the recognition of these precursors in vivo differs from other known miRNAs. Our results describe a link between the evolutionary conservation of plant MIRNAs and the mechanisms underlying the biogenesis of these small RNAs and show that the MIRNA pattern of conservation can be used to infer the mode of miRNA biogenesis. | ca |
dc.format.extent | 13 | ca |
dc.language.iso | eng | ca |
dc.publisher | Oxford University Press | ca |
dc.relation.ispartof | The Plant Cell | ca |
dc.relation.ispartofseries | 29;6 | |
dc.rights | © 2017 American Society of Plant Biologists. All rights reserved. This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model) | ca |
dc.subject.other | Ciències Biològiques | ca |
dc.subject.other | Ciències de les plantes | ca |
dc.subject.other | Ciències forestals | ca |
dc.subject.other | Ciència i matemàtiques | ca |
dc.subject.other | Ciencias Biológicas | ca |
dc.subject.other | Ciencias de las plantas | ca |
dc.subject.other | Ciencias forestales | ca |
dc.subject.other | Ciencia y matemáticas | ca |
dc.subject.other | Biological Sciences | ca |
dc.subject.other | Plant Sciences | ca |
dc.subject.other | Forestry sciences | ca |
dc.subject.other | Science and mathematics | ca |
dc.title | Evolutionary footprints reveal insights into plant MicroRNA biogenesis | ca |
dc.type | info:eu-repo/semantics/article | ca |
dc.description.version | info:eu-repo/semantics/publishedVersion | ca |
dc.rights.accessLevel | info:eu-repo/semantics/openAccess | |
dc.embargo.terms | cap | ca |
dc.subject.udc | 5 | ca |
dc.identifier.doi | https://dx.doi.org/10.1105/tpc.17.00272 | ca |