Discerning the subfibrillar structure of mineralized collagen fibrils: a model for the ultrastructure of bone
Autor/a
Li, Yuping
Aparicio, Conrado
Data de publicació
2013ISSN
1932-6203
Resum
Biomineralization templated by organic molecules to produce inorganic-organic nanocomposites is a fascinating example of nature using bottom-up strategies at nanoscale to accomplish highly ordered multifunctional materials. One such nanocomposite is bone, composed primarily of hydroxyapatite (HA) nanocrystals that are embedded within collagen fibrils with their c-axes arranged roughly parallel to the long axis of the fibrils. Here we discern the ultra-structure of biomimetic mineralized collagen fibrils (MCFs) as consisting of bundles of subfibrils with approximately 10 nm diameter; each one with an organic-inorganic core-shell structure. Through an amorphous calcium phosphate precursor phase the HA nanocrystals were specifically grown along the longitudinal direction of the collagen microfibrils and encapsulated them within the crystal lattice. They intercalated throughout the collagen fibrils such that the mineral phase surrounded the surface of collagen microfibrils forming an interdigitated network. It appears that this arrangement of collagen microfibrils in collagen fibrils is responsible for the observed ultrastructure. Such a subfibrillar nanostructure in MCFs was identified in both synthetic and natural bone, suggesting this is the basic building block of collagen-based hard tissues. Insights into the ultrastructure of mineralized collagen fibrils have the potential to advance our understanding on the biomineralization principles and the relationship between bone’s structure and mechanical properties, including fracture toughness mechanisms. We anticipate that these principles from biological systems can be applied to the rational design of new nanocomposites with improved performance.
Tipus de document
Article
Versió del document
Versió publicada
Llengua
Anglès
Matèries (CDU)
616.3 - Patologia de l'aparell digestiu. Odontologia
Paraules clau
Odontologia
Odontología
Dentistry
Pàgines
12
Publicat per
Public Library of Science
Col·lecció
8;9
Publicat a
PLoS ONE
Citació
Li, Yuping; Aparicio, Conrado. Discerning the subfibrillar structure of mineralized collagen fibrils: a model for the ultrastructure of bone. PLoS One, 2013, 8(9), e76782. Disponible en: <https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0076782>. Fecha de acceso: 19 abr. 2023. DOI: 10.1371/journal.pone.0076782
Enllaç al document relacionat
Aquest element apareix en la col·lecció o col·leccions següent(s)
- Odontologia [228]
Drets
© 2013 Li et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Excepte que s'indiqui una altra cosa, la llicència de l'ítem es descriu com https://creativecommons.org/licenses/by/3.0/es/