Discerning the subfibrillar structure of mineralized collagen fibrils: a model for the ultrastructure of bone
Autor/a
Li, Yuping
Aparicio, Conrado
Fecha de publicación
2013ISSN
1932-6203
Resumen
Biomineralization templated by organic molecules to produce inorganic-organic nanocomposites is a fascinating example of nature using bottom-up strategies at nanoscale to accomplish highly ordered multifunctional materials. One such nanocomposite is bone, composed primarily of hydroxyapatite (HA) nanocrystals that are embedded within collagen fibrils with their c-axes arranged roughly parallel to the long axis of the fibrils. Here we discern the ultra-structure of biomimetic mineralized collagen fibrils (MCFs) as consisting of bundles of subfibrils with approximately 10 nm diameter; each one with an organic-inorganic core-shell structure. Through an amorphous calcium phosphate precursor phase the HA nanocrystals were specifically grown along the longitudinal direction of the collagen microfibrils and encapsulated them within the crystal lattice. They intercalated throughout the collagen fibrils such that the mineral phase surrounded the surface of collagen microfibrils forming an interdigitated network. It appears that this arrangement of collagen microfibrils in collagen fibrils is responsible for the observed ultrastructure. Such a subfibrillar nanostructure in MCFs was identified in both synthetic and natural bone, suggesting this is the basic building block of collagen-based hard tissues. Insights into the ultrastructure of mineralized collagen fibrils have the potential to advance our understanding on the biomineralization principles and the relationship between bone’s structure and mechanical properties, including fracture toughness mechanisms. We anticipate that these principles from biological systems can be applied to the rational design of new nanocomposites with improved performance.
Tipo de documento
Artículo
Versión del documento
Versión publicada
Lengua
Inglés
Materias (CDU)
616.3 - Patología del aparato digestivo. Odontología
Palabras clave
Odontologia
Odontología
Dentistry
Páginas
12
Publicado por
Public Library of Science
Colección
8;9
Publicado en
PLoS ONE
Citación
Li, Yuping; Aparicio, Conrado. Discerning the subfibrillar structure of mineralized collagen fibrils: a model for the ultrastructure of bone. PLoS One, 2013, 8(9), e76782. Disponible en: <https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0076782>. Fecha de acceso: 19 abr. 2023. DOI: 10.1371/journal.pone.0076782
Enlace al documento relacionado
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- Odontologia [228]
Derechos
© 2013 Li et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Excepto si se señala otra cosa, la licencia del ítem se describe como https://creativecommons.org/licenses/by/3.0/es/