Chitosan-recombinamer layer-by-layer coatings for multifunctional implants
Autor/a
Prasaad Govindharajulu, Jeevan
Chen, Xi
Li, Yuping
Battacharya, Mrinal
Data de publicació
2017ISSN
1422-0067
Resum
The main clinical problems for dental implants are (1) formation of biofilm around the implant—a condition known as peri-implantitis and (2) inadequate bone formation around the implant—lack of osseointegration. Therefore, developing an implant to overcome these problems is of significant interest to the dental community. Chitosan has been reported to have good biocompatibility and anti-bacterial activity. An osseo-inductive recombinant elastin-like biopolymer (P-HAP), that contains a peptide derived from the protein statherin, has been reported to induce biomineralization and osteoblast differentiation. In this study, chitosan/P-HAP bi-layers were built on a titanium surface using a layer-by-layer (LbL) assembly technique. The difference in the water contact angle between consecutive layers, the representative peaks in diffuse reflectance infrared Fourier transform spectroscopy (DRIFTS), X-ray photoelectron spectroscopy (XPS), and the changes in the topography between surfaces with a different number of bi-layers observed using atomic force microscopy (AFM), all indicated the successful establishment of chitosan/P-HAP LbL assembly on the titanium surface. The LbL-modified surfaces showed increased biomineralization, an appropriate mouse pre-osteoblastic cell response, and significant anti-bacterial activity against Streptococcus gordonii, a primary colonizer of tissues in the oral environment.
Tipus de document
Article
Versió del document
Versió publicada
Llengua
English
Matèries (CDU)
616.3 - Patologia de l'aparell digestiu. Odontologia
Paraules clau
Quitosà
Recombinamers semblants a l'elastina
Capa per capa
Titani
Implant
Quitosano
Recombinameros de tipo elastina
Capa por capa
Titanio
Implante
Chitosan
Elastin-like recombinamers
Layer-by-layer
Titanium
Implant
Pàgines
16
Publicat per
MDPI
Col·lecció
18; 2
Publicat a
International Journal of Molecular Sciences
Citació
Prasaad Govindharajulu, Jeevan; Chen, Xi; Li, Yuping [et al.]. Chitosan-recombinamer layer-by-layer coatings for multifunctional implants. International Journal of Molecular Sciences, 2017, 18(2), 369. Disponible en: <https://www.mdpi.com/1422-0067/18/2/369<. Fecha de acceso: 19 abr. 2023. DOI: 10.3390/ijms18020369
Enllaç al document relacionat
Aquest element apareix en la col·lecció o col·leccions següent(s)
- Odontologia [245]
Drets
© 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( http://creativecommons.org/licenses/by/4.0/).
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