Chitosan-recombinamer layer-by-layer coatings for multifunctional implants
Autor/a
Prasaad Govindharajulu, Jeevan
Chen, Xi
Li, Yuping
Battacharya, Mrinal
Fecha de publicación
2017ISSN
1422-0067
Resumen
The main clinical problems for dental implants are (1) formation of biofilm around the implant—a condition known as peri-implantitis and (2) inadequate bone formation around the implant—lack of osseointegration. Therefore, developing an implant to overcome these problems is of significant interest to the dental community. Chitosan has been reported to have good biocompatibility and anti-bacterial activity. An osseo-inductive recombinant elastin-like biopolymer (P-HAP), that contains a peptide derived from the protein statherin, has been reported to induce biomineralization and osteoblast differentiation. In this study, chitosan/P-HAP bi-layers were built on a titanium surface using a layer-by-layer (LbL) assembly technique. The difference in the water contact angle between consecutive layers, the representative peaks in diffuse reflectance infrared Fourier transform spectroscopy (DRIFTS), X-ray photoelectron spectroscopy (XPS), and the changes in the topography between surfaces with a different number of bi-layers observed using atomic force microscopy (AFM), all indicated the successful establishment of chitosan/P-HAP LbL assembly on the titanium surface. The LbL-modified surfaces showed increased biomineralization, an appropriate mouse pre-osteoblastic cell response, and significant anti-bacterial activity against Streptococcus gordonii, a primary colonizer of tissues in the oral environment.
Tipo de documento
Artículo
Versión del documento
Versión publicada
Lengua
English
Materias (CDU)
616.3 - Patología del aparato digestivo. Odontología
Palabras clave
Quitosà
Recombinamers semblants a l'elastina
Capa per capa
Titani
Implant
Quitosano
Recombinameros de tipo elastina
Capa por capa
Titanio
Implante
Chitosan
Elastin-like recombinamers
Layer-by-layer
Titanium
Implant
Páginas
16
Publicado por
MDPI
Colección
18; 2
Publicado en
International Journal of Molecular Sciences
Citación
Prasaad Govindharajulu, Jeevan; Chen, Xi; Li, Yuping [et al.]. Chitosan-recombinamer layer-by-layer coatings for multifunctional implants. International Journal of Molecular Sciences, 2017, 18(2), 369. Disponible en: <https://www.mdpi.com/1422-0067/18/2/369<. Fecha de acceso: 19 abr. 2023. DOI: 10.3390/ijms18020369
Enlace al documento relacionado
Este ítem aparece en la(s) siguiente(s) colección(ones)
- Odontologia [248]
Derechos
© 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( http://creativecommons.org/licenses/by/4.0/).
Excepto si se señala otra cosa, la licencia del ítem se describe como https://creativecommons.org/licenses/by/4.0/