Influence of bone-level dental implants placement and of cortical thickness on osseointegration: in silico and in vivo analyses
Author
Publication date
2022ISSN
2077-0383
Abstract
The purpose of this research is to study the biomechanical response of dental implants in bone-level type locations, 0.5 mm above and below the bone level. In addition, the influence of the thickness of the cortical bone on osseointegration is determined due to the mechanical loads transfer from the dental implant to the cortical and trabecular bone. The thicknesses studied were 1.5 mm and 2.5 mm. Numerical simulations were performed using a finite element method (FEM)-based model. In order to verify the FEM model, the in silico results were compared with the results obtained from a histological analysis performed in an in vivo study with 30 New Zealand rabbits. FEM was performed using a computerized 3D model of bone-level dental implants inserted in the lower jawbone with an applied axial load of 100 N. The analysis was performed using different distances from the bone level and different thicknesses of cortical bone. The interface area of bone growth was evaluated by analyzing the bone–implant contact (BIC), region of interest (ROI) and total bone area (BAT) parameters obtained through an in vivo histological process and analyzed by scanning electron microscopy (SEM). Bone-level implants were inserted in the rabbit tibiae, with two implants placed per tibia. These parameters were evaluated after three or six weeks of implantation. FEM studies showed that placements 0.5 mm below the bone level presented lower values of stress distribution compared to the other studied placements. The lower levels of mechanical stress were then correlated with the in vivo studies, showing that this position presented the highest BIC value after three or six weeks of implantation. In this placement, vertical bone growth could be observed up the bone level. The smallest thickness of the study showed a better transfer of mechanical loads, which leads to a better osseointegration. In silico and in vivo results both concluded that the implants placed 0.5 mm below the cortical bone and with lower thicknesses presented the best biomechanical and histological behavior in terms of new bone formation, enhanced mechanical stability and optimum osseointegration.
Document Type
Article
Document version
Published version
Language
English
Subject (CDU)
616.3 - Pathology of the digestive system. Complaints of the alimentary canal
Keywords
Osteointegració
Os
Implants dentals
Os cortical
En viu
Histologia
Osteointegración
Hueso
Implantes dentales
Hueso cortical
En vivo
Histología
Osseointegration
Bone
Dental implants
Cortical bone
In vivo
Histology
Pages
15
Publisher
MDPI
Collection
11; 4
Is part of
Journal of Clinical Medicine
Citation
Gil, FJ.; Sandino, Clara; Cerrolaza, Miguel [et al.]. Influence of bone-level dental implants placement and of cortical thickness on osseointegration: in silico and in vivo analyses. Journal of Clinical Medicine, 2022, 11(4), 1027. Disponible en: <https://www.mdpi.com/2077-0383/11/4/1027>. Fecha de acceso: 21 mar. 2023. DOI: 10.3390/jcm11041027
Link to the related item
This item appears in the following Collection(s)
- Ciències Bàsiques [65]
Rights
© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
Except where otherwise noted, this item's license is described as https://creativecommons.org/licenses/by/4.0/