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Defective in mitotic arrest 1 (Dma1) ubiquitin ligase controls G1 cyclin degradation
(American Society for Biochemistry and Molecular Biology, 2013-02)
Progression through the G1 phase of the cell cycle is controlled by diverse cyclin-dependent kinases (CDKs) that might be associated to numerous cyclin isoforms. Given such complexity, regulation of ...
Changes in invasive pneumococcal disease caused by streptococcus pneumoniae serotype 1 following introduction of PCV10 and PCV13: findings from the PSERENADE project
(MDPI, 2021)
Streptococcus pneumoniae serotype 1 (ST1) was an important cause of invasive pneumococcal disease (IPD) globally before the introduction of pneumococcal conjugate vaccines (PCVs) containing ST1 antigen. ...
Understanding perceived availability and importance of tobacco control interventions to inform European adoption of a UK economic model: a cross-sectional study
(BMC, 2018-02-14)
Background:
The evidence on the extent to which stakeholders in different European countries agree with availability and importance of tobacco-control interventions is limited. This study assessed and ...
Feeding the brain: effect of nutrients on cognition, synaptic function, and AMPA receptors
(MDPI, 2022)
In recent decades, traditional eating habits have been replaced by a more globalized diet, rich in saturated fatty acids and simple sugars. Extensive evidence shows that these dietary factors contribute ...
Strategic discussion on funding and access to therapies targeting rare diseases in Spain: an expert consensus paper
(Springer Nature, 2023)
Background: In recent years, significant advances have been made in the field of rare diseases (RDs). However, there is a large number of RDs without specific treatment and half of these treatments have ...
Long-term anatomical and functional survival of Boston type 1 keratoprosthesis in congenital aniridia
(Frontiers Media, 2021)
Purpose: To analyze the long-term anatomical survival, functional survival, and complications of Boston type 1 keratoprosthesis (KPro) in the eyes with congenital aniridia-associated keratopathy (AAK). ...
The quantitative changes in the yeast Hsp70 and Hsp90 interactomes upon DNA damage
(Elsevier, 2015-03)
The molecular chaperones Hsp70 and Hsp90 participate in many important cellular processes, including how cells respond to DNA damage. Here we show the results of applied quantitative affinity-purification ...
Skin cancer classification via convolutional neural networks: systematic review of studies involving human experts
(Elsevier, 2021-10)
Background: Multiple studies have compared the performance of artificial intelligence (AI)–based models for automated skin cancer classification to human experts, thus setting the cornerstone for a ...
The persistent breach between evidence and practice in the prevention of surgical site infection. Qualitative study
(Elsevier, 2020)
Background: Despite the dissemination of guidelines for surgical site infection (SSI) prevention, a gap between the theoretical measures and their compliance persists. Accurate estimates of the ...
Pneumococcal nasopharyngeal carriageamong Bhutanese children hospitalizedwith clinical pneumonia: serotypes andviral co-infection
(Springer Nature, 2020-12)
Background: Pneumococcal nasopharyngeal colonization (PNC) generally precedes pneumococcal disease. The purpose of this study was to determine the prevalence of PNC and to identify the pneumococcal ...