Browsing by Subject "Transcriptional regulation"

Now showing items 1-2 of 2

ADP-ribose–derived nuclear ATP synthesis by NUDIX5 is required for chromatin remodeling

Wright, Roni; LeDily, Francois; Soronellas, Daniel; Pohl, Andy; Bonet, Jaume; Nacht, A. S.; Vicent, Guillermo Pablo; Wierer, Michael; Oliva, Baldomero; Beato, Miguel (Science, 2016)

Key nuclear processes in eukaryotes, including DNA replication, repair, and gene regulation, require extensive chromatin remodeling catalyzed by energy-consuming enzymes. It remains unclear how the ATP ...
Distinct structural transitions of chromatin topological domains correlate with coordinated hormone-induced gene regulation

Le Dily, François; Bau, Davide; Pohl, Andy; Vicent, Guillermo P.; Serra, Francois; Soronellas, Daniel; Castellano, Giancarlo; Wright, Roni; Ballare, Cecilia; Filion, Guillaume; Marti-Renom, Marc A.; Beato, Miguel (Genes & Development, 2014)

The human genome is segmented into topologically associating domains (TADs), but the role of this conserved organization during transient changes in gene expression is not known. Here we describe the ...