Browsing by Subject "Ciclo celular"
Now showing items 1-10 of 10
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Atypical cyclins: the extended family portrait
(Cellular and Molecular Life Sciences, 2020)Regulation of cell division is orchestrated by cyclins, which bind and activate their catalytic workmates, the cyclin-dependent kinases (CDKs). Cyclins have been traditionally defined by an oscillating ... -
Caracterización cuantitativa de las ciclinas de la fase G1 del ciclo celular en Saccharomyces cerevisiae
(Date of defense: 2017-11-07)Saccharomyces cerevisiae és un microorganisme unicel·lular eucariota que per presentar el seu genoma totalment seqüenciat, gran facilitat de manipulació en el treball de laboratori, ja que molts dels ... -
Caracterización de complejos CDK-Ciclina atípicos humanos
(Date of defense: 2018-03-15)La desregulación en los mecanismos de control del ciclo celular es un evento indiscutiblemente asociado a la aparición de diversas patologías, entre las que destacan los procesos tumorales. Como principales ... -
CDKN1A/p21 in breast cancer: part of the problem, or part of the solution?
(International Journal of Molecular Sciences, 2023)Cyclin-dependent kinase inhibitor 1A (Cip1/Waf1/CDKN1A/p21) is a well-established protein, primarily recognised for its pivotal role in the cell cycle, where it induces cell cycle arrest by inhibiting ... -
Control de la estabilidad de ciclinas de G1 por nutrientes
(Date of defense: 2014-07-31)El control del ciclo celular está altamente regulado mediante diferentes CDKs asociadas a ciclinas. En Saccharomyces cerevisiae, la CDK esencial Cdc28 es la que regula mayoritariamente este proceso. En ... -
El polifosfat és un element clau durant la replicació del DNA.
(Date of defense: 2015-11-06)Throughout its lifespan, eukaryotic cells steadily consume free cytoplasmic orthophosphate to produce phospholipids and mRNA. However, during DNA synthesis, in a matter of minutes, cells require large ... -
Iron Regulation and the Cell Cycle: identification of an iron-responsive element in the 3′-untranslated region of human cell division cycle 14a mrna by a refined microarray-based screening strategy
(The Journal of Biological Chemistry, 2006)Iron regulatory proteins (IRPs) 1 and 2 post-transcriptionally control mammalian iron homeostasis by binding to iron-responsive elements (IREs), conserved RNA stem-loop structures located in the 5′- or ... -
Mad3 modulates the G1 Cdk and acts as a timer in the Start network
(Science Advances, 2022)Cells maintain their size within limits over successive generations to maximize fitness and survival. Sizer, timer, and adder behaviors have been proposed as possible alternatives to coordinate growth ... -
Nutrient availability regulates cell cycle through a Pho85 CDK-dependent control of Cln3 cyclin stability
(Date of defense: 2013-02-04)Cell cycle control by trophic factors has a key role in regulation of cell proliferation in all organisms. Nutrients are one of these important factors needed by cells to reproduce, so very well regulated ... -
Signalling network of breast cancer cells in response to progesterone
(BioRxiv, 2020)Breast cancer cells enter into the cell cycle following progestin exposure by the activation of signalling cascades involving a plethora of enzymes, transcription factors and co-factors that transmit ...