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Listando por materia "Obesity"

Mostrando ítems 1-20 de 26

    • Alternate-day fasting differentially affects body composition, metabolic and immune response to fasting in male rats exposed to early-life adversity: modulatory role of cafeteria diet 

      Sagae, Sara C.; Paz, Edson D. R.; Zanardini, Bárbara; Amaral, Ana Claudia; Bronczek, Gabriela A.; Koehler-Santos, Patrícia; de Oliveira, Jarbas R.; Franci, Celso R.; Donadio, Márcio V. F.; Holman, Parker J.; Raineki, Charlis (PLoS ONE, 2025)
      The increased risk for obesity and metabolic disorders following early-life adversity is aggravated by poor diet (e.g., cafeteria diet). Alternate-day fasting (ADF) is a dietary regimen shown to improve ...

    • Assessment of a school-based intervention in eating habits and physical activity in school children: the AVall study 

      Llargués Rocabruna, Esteve; Franco, Rosa; Recasens, Assumpta; Nadal, Ana; Vila, Maria; Pérez, Maria José; Manresa, Josep Maria; Recasens, Isabel; Salvador, Gemma; Serra, Jaume; Roure, Eulàlia; Castells, Conxa (Journal of Epidemiology and Community Health, 2011)
      Background: Obesity has become a global public health problem, which also affects children. It has been proposed that the educational interventions during childhood could be a key strategy in the ...

    • Association between kidney function, nutritional status and anthropometric measures in older people: the screening for CKD among older people across Europe (SCOPE) study 

      Guligowska, Agnieszka; Corsonello, Andrea; Pigłowska, Małgorzata; Roller-Wirnsberger, Regina; Wirnsberger, Gerhard; Ärnlöv, Johan; Carlsson, Axel C.; Tap, Lisanne; Mattace-Raso, Francesco; Formiga, Francesc; Moreno-Gónzalez, Rafael; Freiberger, Ellen; Sieber, Cornel; Gregorio, Pedro Gil; Laínez Martínez, Sara; Artzi-Medvedik, Rada; Yehoshua, Ilan; Fabbietti, Paolo; Lattanzio, Fabrizia; Kostka, Tomasz; SCOPE investigators; Corbella Virós, Xavier (BMC Geriatrics, 2020-10-02)
      Background: Different mechanisms connect the nutritional status with the occurrence and the course of chronic kidney disease (CKD). The end-stage renal disease is complicated by catabolic inflammatory ...

    • Central ceramide-induced hypothalamic lipotoxicity and ER stress regulate energy balance 

      Contreras, Cristina; González-García, Ismael; Martínez-Sánchez, Noelia; Seoane-Collazo, Patricia; Jacas i Mateu, Jordi; Morgan, Donald A.; Serra, Dolors; Gallego, Rosalía; Gonzalez, Francisco; Casals i Farré, Núria; Nogueiras, Rubén; Rahmouni, Kamal; Diéguez, Carlos; López, Miguel (Cell Reports, 2014-10)
      Hypothalamic endoplasmic reticulum (ER) stress is a key mechanism leading to obesity. Here, we demonstrate that ceramides induce lipotoxicity and hypothalamic ER stress, leading to sympathetic inhibition, ...

    • Central regulation of brown fat thermogenesis in response to saturated or unsaturated long-chain fatty acids 

      Fosch Masllovet, Anna; Rodríguez García, Maria; Miralpeix , Cristina; Zagmutt, Sebastián; Larrañaga Fernandez, Maite; Reguera, Ana Cristina; Garcia-Chica, Jesus; Herrero, Laura; Serra, Dolors; Casals, Nuria; Rodriguez-Rodriguez, Rosalia (International Journal of Molecular Sciences, 2023)
      Sensing of long-chain fatty acids (LCFA) in the hypothalamus modulates energy balance, and its disruption leads to obesity. To date, the effects of saturated or unsaturated LCFA on hypothalamic-brown ...

    • CPT1c in specific hypothalamic nuclei and its role in lipid sensing and metabolic adaptation 

      Fosch Masllovet, Anna (Fecha de defensa: 2022-09-23)
      Obesity has become a pandemic disease in the last 40 years. The WHO estimates that the population with overweight has nearly tripled since 1975, and the tendency is still growing. These data have an ...

    • CPT1C in the ventromedial nucleus of the hypothalamus is necessary for brown fat thermogenesis activation in obesity 

      Rodríguez-Rodríguez, Rosalía; Miralpeix Monclús, Cristina; Fosch, Anna; Pozo Ariza, Macarena; Calderón-Domínguez, María; Perpinyà, Xavier; Vellvehí, Miquel; López, Miguel; Herrero Rodríguez, Laura; Serra, Dolors; Casals i Farré, Núria (Molecular Metabolism, 2019-01)
      Objective: Carnitine palmitoyltransferase 1C (CPT1C) is implicated in central regulation of energy homeostasis. Our aim was to investigate whether CPT1C in the ventromedial nucleus of the hypothalamus ...

    • Current challenges for targeting brown fat thermogenesis to combat obesity 

      Yoneshiro, Takeshi; Rodríguez-Rodríguez, Rosalía; Johannes Betz, Matthias; Rensen, Patrick C. N. (Frontiers in Endocrinology, 2020-10-27)
      Just over a decade has passed since metabolically active brown adipose tissue (BAT) was unequivocally identified in healthy adult humans. Since then, researchers have provided evidence of expression of ...

    • Detección precoz de los factores de riesgo cardiovasculares en los centros de atención primaria de Cataluña central 

      Senent López, Rosa Mª (2014-06-26)
      Las enfermedades cardiovasculares son actualmente la principal causa de muerte prematura, por lo que es necesario controlar los factores que podrían reducir el riesgo cardiovascular. El presente estudio ...

    • Development of C75-CoA loaded polymeric micelles targeting brain CPT1A: A novel nanomedicine-based approach to fight obesity and cancer 

      García-Chica, Jesús (Fecha de defensa: 2024-02-14)
      Brain lipid metabolism has a key role in many physiological processes, and its malfunction is associated with a plethora of diseases, such as obesity and glioblastoma multiforme (GBM). Carnitine palmitoyl ...

    • Editorial: current challenges for targeting brown fat thermogenesis to combat obesity 

      Yoneshiro, Takeshi; Rodríguez-Rodríguez, Rosalía; Johannes Betz, Matthias; Rensen, Patrick C. N. (Frontiers in Endocrinology, 2020-10-27)
      Just over a decade has passed since metabolically active brown adipose tissue (BAT) was unequivocally identified in healthy adult humans. Since then, researchers have provided evidence of expression of ...

    • Four-year outcomes of an educational intervention in healthy habits in schoolchildren: the Avall 3 Trial 

      Llargués Rocabruna, Esteve; Recasens, Ma. Assumpta; Manresa, Josep-Maria; Jensen, Bjarne Bruun; Franco, Rosa; Nadal, Anna; Vila, Maria; Recasens, Isabel; Pérez, M. José; Castell, Conxa (European Journal of Public Health, 2016)
      Background: The prevalence of obesity among children is increasing, but treating obesity is difficult and has poor outcomes. We assessed the 4-year impact of a school-based educational intervention on ...

    • How do consumers respond to “sin taxes”? New evidence from a tax on sugary drinks 

      Fichera, Eleonora; Mora, Toni; G Lopez-Valcarcel, Beatriz; Roche, David (Social Science & Medicine, 2021-04)
      It is unclear what the effects of taxes on sugar sweetened beverages (SSBs) are on consumer behaviour and which consumers may be affected the most. We evaluate the effect of the SSB tax introduced in ...

    • Hypothalamic AMPK-ER Stress-JNK1 axis mediates the central actions of thyroid hormones on energy balance 

      Martinez-Sanchez, Noelia; Seoane-Collazo, Patricia; Contreras, Cristina; Varela, Luis; Villarroya, Joan; Rial-Pensado, Eva; Buque, Xabier; Aurrekoetxea, Igor; Delgado, Teresa C.; Vazquez-Martinez, Rafael; Gonzalez-Garcia, Ismael; Roa, Juan; Whittle, Andrew J.; Gomez-Santos, Beatriz; Velagapudi, Vidya; Loraine Tung, Y. C.; Morgan, Donald A.; Voshol, Peter J.; Martinez de Morentin, Pablo B.; Lopez-Gonzalez, Tania; Linares-Pose, Laura; Gonzalez, Francisco; Chatterjee, Krishna; Sobrino, Tomas; Medina-Gomez, Gema; Davis, Roger J.; Casals i Farré, Núria; Oresic, Matej; Coll, Anthony P.; Vidal-Puig, Antonio; Mittag, Jens; Tena-Sempere, Manuel; Malagon, Maria M.; Dieguez, Carlos; Martinez-Chantar, Maria Luz; Aspichueta, Patricia; Rahmouni, Kamal; Nogueiras, Rubén; Sabio, Guadalupe; Villarroya, Francesc; Lopez, Miguel (Cell Metabolism, 2017-07)
      Thyroid hormones (THs) act in the brain to modulate energy balance. We show that central triiodothyronine (T3) regulates de novo lipogenesis in liver and lipid oxidation in brown adipose tissue (BAT) ...

    • Hypothalamic endocannabinoids in obesity: an old story with new challenges 

      Miralpeix , Cristina; Reguera, Ana Cristina; Fosch, Anna; Zagmutt, Sebastián; Casals i Farré, Núria; Cota, Daniela; Rodríguez-Rodríguez, Rosalía (Cellular and Molecular Life Sciences, 2021)
      The crucial role of the hypothalamus in the pathogenesis of obesity is widely recognized, while the precise molecular and cellular mechanisms involved are the focus of intense research. A disrupted ...

    • Hypothalamic endocannabinoids inversely correlate with the development of diet-induced obesity in male and female mice 

      Miralpeix Monclús, Cristina; Fosch, Anna; Casas, Josefina; Baena, Miguel; Herrero Rodríguez, Laura; Serra, Dolors; Rodríguez-Rodríguez, Rosalía; Casals i Farré, Núria (Journal of Lipid Research, 2019-07)
      The endocannabinoid (eCB) system regulates energy homeostasis and is linked to obesity development. However, the exact dynamic and regulation of eCBs in the hypothalamus during obesity progression remain ...

    • Hypothalamic regulation of obesity 

      Rodríguez-Rodríguez, Rosalía; Miralpeix , Cristina (International Journal of Molecular Sciences, 2021)
      Obesity has now reached pandemic proportions and represents a major socioeconomic and health problem in our societies. Up to now, obesity has been considered a medical issue only in high-income countries, ...

    • Identification of the ghrelin and cannabinoid CB2 receptor heteromer functionality and marked upregulation in striatal neurons from offspring of mice under a high-fat diet 

      Lillo, Jaume; Lillo, Alejandro; Zafra, David A.; Miralpeix Monclús, Cristina; Rivas-Santisteban, Rafael; Casals i Farré, Núria; Navarro, Gemma; Franco, Rafael (International Journal of Molecular Sciences, 2021)
      Cannabinoids have been reported as orexigenic, i.e., as promoting food intake that, among others, is controlled by the so-called “hunger” hormone, ghrelin. The aim of this paper was to look for functional ...

    • Impact of school-based nutrition and physical activity intervention on body mass index eight years after cessation of randomized controlled trial (AVall study) 

      Recasens, Ma. Assumpta; Coromina, Eva Xicola; Manresa, Josep-Maria; Ullmo, Pierre Antoine; Jensen, Bjarne Bruun; Franco, Rosa; Suarez, Anna; Nadal, Anna; Vila, Maria; Recasens, Isabel; Pérez, M. José; Castell, Conxa; Llargués, Esteve (Clinical Nutrition, 2019)
      Background & aims: The prevalence of obesity and overweight among children is increasing, representing a new and pressing societal problem. Excess weight in childhood is an independent risk factor for ...

    • Implantation of CPT1AM-expressing adipocytes reduces obesity and glucose intolerance in mice 

      Soler Vázquez, M. Carmen; Romero, María del Mar; Todorcevic, Marijana; Delgado, Katia; Calatayud, Carles; Benítez Amaro, Aleyda; La Chica Lhoëst, María Teresa; Mera, Paula; Zagmutt, Sebastián; Bastías Pérez, Marianela Pía ; Ibeas, Kevin; Casals, Núria; Escola-Gil, Joan Carles; Llorente Cortés, Vicenta; Consiglio, Antonella; Serra, Dolors; Herrero, Laura (Metabolic Engineering, 2023-05)
      Obesity and its associated metabolic comorbidities are a rising global health and social issue, with novel therapeutic approaches urgently needed. Adipose tissue plays a key role in the regulation of ...