Browsing by Subject "576"
Now showing items 1-13 of 13
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Caracterización de complejos CDK-Ciclina atípicos humanos
(Date of defense: 2018-03-15)La desregulación en los mecanismos de control del ciclo celular es un evento indiscutiblemente asociado a la aparición de diversas patologías, entre las que destacan los procesos tumorales. Como principales ... -
Comprehensive and quantitative analysis of G1 cyclins. A tool for studying the cell cycle
(PLoS One, 2019-06-25)In eukaryotes, the cell cycle is driven by the actions of several cyclin dependent kinases (CDKs) and an array of regulatory proteins called cyclins, due to the cyclical expression patterns of the latter. ... -
Control de la estabilidad de ciclinas de G1 por nutrientes
(Date of defense: 2014-07-31)El control del ciclo celular está altamente regulado mediante diferentes CDKs asociadas a ciclinas. En Saccharomyces cerevisiae, la CDK esencial Cdc28 es la que regula mayoritariamente este proceso. En ... -
Desarrollo de nuevos métodos para el análisis del polifosfato en células humanas
(Date of defense: 2023-11-20)Nombre / Nom / Name Ana Apellidos / Cognoms / Surname Sarrias Giménez Dirección de correo electrónico / Adreça de correu electrònic / email address (opcional / optional) anasargim@gmail.com Departamento ... -
Estudi de la ciclina atípica CCNI com a potencial activador de CDK6 en línies de càncer de mama
(Date of defense: 2022-02-09)Fa quasi 40 anys del descobriment de les ciclines, les proteïnes oscil·lants tradicionalment dividies en dos grups, “cicle cel·lular” i “ciclines transcripcionals”, que duen a terme els seus rols juntament ... -
Extracellular UTP signalling in Schwann cell migration: A novel role of the P2Y2 receptor
(Date of defense: 2013-09-24)Peripheral neuropaties are one of the major complications of the Peripheral Nervous System. Depsite the big importance of those pathologies, less drugs are effective for their treatment, and most of the ... -
G1-Cdk modulation by time and stress
(Date of defense: 2022-09-23)The cell cycle is regulated at different layers of control in either homeostatic or non-homeostatic conditions. Hence, in this work we analyse how time and stress modulate the cell cycle through the ... -
Hypothalamic Ceramide Levels regulated by CPT1C mediate the Orexigenic effect of Ghrelin
(Date of defense: 2014-07-31)Recent data suggest that ghrelin exerts its orexigenic action through regulation of hypothalamic AMP-activated protein kinase pathway, leading to a decline in malonyl-CoA levels and desinhibition of ... -
Mad3 modulates the G1 Cdk and acts as a timer in the Start network
(Science Advances, 2022)Cells maintain their size within limits over successive generations to maximize fitness and survival. Sizer, timer, and adder behaviors have been proposed as possible alternatives to coordinate growth ... -
Nutrient availability regulates cell cycle through a Pho85 CDK-dependent control of Cln3 cyclin stability
(Date of defense: 2013-02-04)Cell cycle control by trophic factors has a key role in regulation of cell proliferation in all organisms. Nutrients are one of these important factors needed by cells to reproduce, so very well regulated ... -
Regulación del ciclo celular por ploidía en Saccharomyces cerevisiae
(Date of defense: 2018-02-02)Una de les característiques cel·lulars amb més impacte sobre la seva fisiologia cel·lular és la mida, regulada per multitud de factors extrínsecs i intrínsecs, i una característica de vital rellevància ... -
Rol de CPT1C en la supervivencia de las células madre mesenquimales
(Date of defense: 2016-09-06)La carnitina palmitoiltransferasa 1C (CPT1C) pertenece a la familia de enzimas CPT1, las cuales controlan la entrada de ácidos grasos al lumen de la mitocondria para su posterior oxidación. Sin embargo, ... -
Role of CPT1C in breast cancer development and chemoresistance
(Date of defense: 2021-07-14)Carnitine palmitoyl transferase 1 (CPT1) are enzymes that catalyze the conversion of long-chain acyl-CoA to acyl-carnitines, to transport long-chain fatty acids across intracellular membranes. CPT1C ...