• ADP-ribose–derived nuclear ATP synthesis by NUDIX5 is required for chromatin remodeling 

      Wright, Roni; LeDily, Francois; Soronellas, Daniel; Pohl, Andy; Bonet, Jaume; Nacht, A. S.; Vicent, Guillermo Pablo; Wierer, Michael; Oliva, Baldomero; Beato, Miguel (Science, 2016)
      Key nuclear processes in eukaryotes, including DNA replication, repair, and gene regulation, require extensive chromatin remodeling catalyzed by energy-consuming enzymes. It remains unclear how the ATP ...
    • Global signalling network analysis of luminal T47D breast cancer cells in response to progesterone 

      Wright, Roni; Vastolo, Viviana; Quilez, Javier; Carbonell Caballero, José; Beato, Miguel (Frontiers in Endocrinology, 2022)
      Background: Breast cancer cells enter into the cell cycle following progestin exposure by the activation of signalling cascades involving a plethora of enzymes, transcription factors and co-factors that ...
    • Modeling cell adhesion and proliferation: a cellular-automata based approach 

      Vivas, J.; Garzón Alvarado, D.; Cerrolaza, Miguel (Advanced Modeling and Simulation in Engineering Sciences, 2015)
      Background: Cell adhesion is a process that involves the interaction between the cell membrane and another surface, either a cell or a substrate. Unlike experimental tests, computer models can simulate ...