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Visualitzant per matèria "DNA damage"

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    • El polifosfat és un element clau durant la replicació del DNA. 

      Bru Rullo, Samuel (Data de defensa: 2015-11-06)
      Throughout its lifespan, eukaryotic cells steadily consume free cytoplasmic orthophosphate to produce phospholipids and mRNA. However, during DNA synthesis, in a matter of minutes, cells require large ...

    • Polyphosphate degradation by Nudt3-Zn2+ mediates oxidative stress response 

      Samper Martín, Bàrbara; Sarrias, Ana; Lázaro, Blanca; Pérez-Montero, Marta; Rodríguez-Rodríguez, Rosalía; P.C. Ribeiro, Mariana; Bañón, Aitor; Wolfgeher, Donald; Jessen, Henning J.; Alsina, Berta; Clotet Erra, Josep; Kron, Stephen J.; Saiardi, Adolfo; Jiménez, Javier; Bru Rullo, Samuel (Cell Reports, 2021)
      Polyphosphate (polyP) is a polymer of hundreds of phosphate residues present in all organisms. In mammals, polyP is involved in crucial physiological processes, including coagulation, inflammation, and ...

    • Tissue-engineered mucosa is a suitable model to quantify the acute biological effects of ionizing radiation 

      Tra, W. M. W.; Tuk, B.; Van Neck, J. W.; Hovius, S. E. R.; Perez Amodio, Soledad (International Journal of Oral and Maxillofacial Surgery, 2025)
      The aim of this study was to evaluate the suitability of tissue-engineered mucosa (TEM) as a model for studying the acute effects of ionizing radiation (IR) on the oral mucosa. TEM and native non-keratinizing ...