comTAR: a web tool for the prediction and characterization of conserved microRNA targets in plants
Author
Chorostecki, Uciel
Palatnik, Javier F.
Publication date
2014ISSN
1367-4811
Abstract
Motivation: MicroRNAs (miRNAs) are major regulators of gene expression in plants and animals. They recognize their target messenger RNAs (mRNAs) by sequence complementarity and guide them to cleavage or translational arrest. So far, the prediction of plant miRNA–target pairs generally relies on the use of empirical parameters deduced from known miRNA–target interactions. Results: We developed comTAR, a web tool for the prediction of miRNA targets that is mainly based on the conservation of the potential regulation in different species. We used data generated from a pipeline applied to transcript datasets of 33 angiosperms that was used to build a database of potential miRNA targets of different plant species. The database contains information describing each miRNA–target pair, their function and evolutionary conservation, while the results are displayed in a user-friendly interface. The tool also allows the search using new miRNAs.
Document Type
Article
Document version
Published version
Language
English
Subject (CDU)
5 - Natural Sciences
Keywords
Bioinformàtica i Biologia Computacional
Ciències Biològiques
Ciència i Matemàtiques
Bioinformática y Biología Computacional
Ciencias Biológicas
Ciencias y Matemáticas
Bioinformatics and Computational Biology
Biological Sciences
Science and Mathematics
Pages
2
Publisher
Oxford University Press
Collection
30;14
Is part of
Bioinformatics
Citation
Chorostecki, Uciel; Palatnik, Javier F. comTAR: a web tool for the prediction and characterization of conserved microRNA targets in plants. Bioinformatics, 2014, 30(14), p. 2066-2067. Disponible en: <https://academic.oup.com/bioinformatics/article/30/14/2066/2390299>. Fecha de acceso: 7 feb. 2024. DOI: 10.1093/bioinformatics/btu147
This item appears in the following Collection(s)
- Ciències Bàsiques [65]
Rights
© The Author 2014. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com