comTAR: a web tool for the prediction and characterization of conserved microRNA targets in plants
Autor/a
Chorostecki, Uciel
Palatnik, Javier F.
Fecha de publicación
2014ISSN
1367-4811
Resumen
Motivation: MicroRNAs (miRNAs) are major regulators of gene expression in plants and animals. They recognize their target messenger RNAs (mRNAs) by sequence complementarity and guide them to cleavage or translational arrest. So far, the prediction of plant miRNA–target pairs generally relies on the use of empirical parameters deduced from known miRNA–target interactions. Results: We developed comTAR, a web tool for the prediction of miRNA targets that is mainly based on the conservation of the potential regulation in different species. We used data generated from a pipeline applied to transcript datasets of 33 angiosperms that was used to build a database of potential miRNA targets of different plant species. The database contains information describing each miRNA–target pair, their function and evolutionary conservation, while the results are displayed in a user-friendly interface. The tool also allows the search using new miRNAs.
Tipo de documento
Artículo
Versión del documento
Versión publicada
Lengua
Inglés
Materias (CDU)
5 - Ciencias puras y naturales
Palabras clave
Bioinformàtica i Biologia Computacional
Ciències Biològiques
Ciència i Matemàtiques
Bioinformática y Biología Computacional
Ciencias Biológicas
Ciencias y Matemáticas
Bioinformatics and Computational Biology
Biological Sciences
Science and Mathematics
Páginas
2
Publicado por
Oxford University Press
Colección
30;14
Publicado en
Bioinformatics
Citación
Chorostecki, Uciel; Palatnik, Javier F. comTAR: a web tool for the prediction and characterization of conserved microRNA targets in plants. Bioinformatics, 2014, 30(14), p. 2066-2067. Disponible en: <https://academic.oup.com/bioinformatics/article/30/14/2066/2390299>. Fecha de acceso: 7 feb. 2024. DOI: 10.1093/bioinformatics/btu147
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Derechos
© The Author 2014. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com