90 years of progesterone: molecular mechanisms of progesterone receptor action on the breast cancer genome
Author
Beato, Miguel
Wright, Roni H.G.
Le Dily, François
Publication date
2020ISSN
0952-5041
Abstract
Gene regulation by steroid hormones has been at the forefront in elucidating the intricacies of transcriptional regulation in eukaryotes ever since the discovery by Karlson and Clever that the insect steroid hormone ecdysone induces chromatin puffs in giant chromosomes. After the successful cloning of the hormone receptors toward the end of the past century, detailed mechanistic insight emerged in some model systems, in particular the MMTV provirus. With the arrival of next generation DNA sequencing and the omics techniques, we have gained even further insight into the global cellular response to steroid hormones that in the past decades also extended to the function of the 3D genome topology. More recently, advances in high resolution microcopy, single cell genomics and the new vision of liquid-liquid phase transitions in the context of nuclear space bring us closer than ever to unravelling the logic of gene regulation and its complex integration of global cellular signaling networks. Using the function of progesterone and its cellular receptor in breast cancer cells, we will briefly summarize the history and describe the present extent of our knowledge on how regulatory proteins deal with the chromatin structure to gain access to DNA sequences and interpret the genomic instructions that enable cells to respond selectively to external signals by reshaping their gene regulatory networks.
Document Type
Article
Document version
Published version
Language
English
Subject (CDU)
61 - Medical sciences
616 - Pathology. Clinical medicine
Keywords
Hormones esteroides
Mecanismes moleculars
Receptor de progesterona
Càncer de mama
Genoma
Hormonas esteroides
Mecanismos moleculares
Receptor de progesterona
Cáncer de mama
Genoma
Steroid hormones
Molecular mechanisms
Progesterone receptor
Breast cancer
Genome
Pages
15
Publisher
Bioscientifica Ltd.
Collection
65;1
Is part of
Journal of Molecular Endocrinology
Citation
Beato, Miguel; Wright, Roni H. G.; Le Dily, François. 90 years of progesterone: molecular mechanisms of progesterone receptor action on the breast cancer genome. Journal of Molecular Endocrinology, 2020, 65(1), T65–T79. Disponible en: <https://jme.bioscientifica.com/configurable/content/journals$002fjme$002f65$002f1$002fJME-19-0266.xml?t%3Aac=journals%24002fjme%24002f65%24002f1%24002fJME-19-0266.xml&body=contentSummary-10201>. Fecha de acceso: 13 dic. 2021. DOI: 10.1530/JME-19-0266
This item appears in the following Collection(s)
- Ciències de la Salut [725]
Rights
© 2020 The authors. Published by Bioscientifica Ltd. Printed in Great Britain. This work is licensed under a Creative Commons Attribution 4.0 International License.
Except where otherwise noted, this item's license is described as https://creativecommons.org/licenses/by/4.0/