90 years of progesterone: molecular mechanisms of progesterone receptor action on the breast cancer genome
Autor/a
Beato, Miguel
Wright, Roni H.G.
Le Dily, François
Fecha de publicación
2020ISSN
0952-5041
Resumen
Gene regulation by steroid hormones has been at the forefront in elucidating the intricacies of transcriptional regulation in eukaryotes ever since the discovery by Karlson and Clever that the insect steroid hormone ecdysone induces chromatin puffs in giant chromosomes. After the successful cloning of the hormone receptors toward the end of the past century, detailed mechanistic insight emerged in some model systems, in particular the MMTV provirus. With the arrival of next generation DNA sequencing and the omics techniques, we have gained even further insight into the global cellular response to steroid hormones that in the past decades also extended to the function of the 3D genome topology. More recently, advances in high resolution microcopy, single cell genomics and the new vision of liquid-liquid phase transitions in the context of nuclear space bring us closer than ever to unravelling the logic of gene regulation and its complex integration of global cellular signaling networks. Using the function of progesterone and its cellular receptor in breast cancer cells, we will briefly summarize the history and describe the present extent of our knowledge on how regulatory proteins deal with the chromatin structure to gain access to DNA sequences and interpret the genomic instructions that enable cells to respond selectively to external signals by reshaping their gene regulatory networks.
Tipo de documento
Artículo
Versión del documento
Versión publicada
Lengua
Inglés
Materias (CDU)
61 - Medicina
616 - Patología. Medicina clínica. Oncología
Palabras clave
Hormones esteroides
Mecanismes moleculars
Receptor de progesterona
Càncer de mama
Genoma
Hormonas esteroides
Mecanismos moleculares
Receptor de progesterona
Cáncer de mama
Genoma
Steroid hormones
Molecular mechanisms
Progesterone receptor
Breast cancer
Genome
Páginas
15
Publicado por
Bioscientifica Ltd.
Colección
65;1
Publicado en
Journal of Molecular Endocrinology
Citación
Beato, Miguel; Wright, Roni H. G.; Le Dily, François. 90 years of progesterone: molecular mechanisms of progesterone receptor action on the breast cancer genome. Journal of Molecular Endocrinology, 2020, 65(1), T65–T79. Disponible en: <https://jme.bioscientifica.com/configurable/content/journals$002fjme$002f65$002f1$002fJME-19-0266.xml?t%3Aac=journals%24002fjme%24002f65%24002f1%24002fJME-19-0266.xml&body=contentSummary-10201>. Fecha de acceso: 13 dic. 2021. DOI: 10.1530/JME-19-0266
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Derechos
© 2020 The authors. Published by Bioscientifica Ltd. Printed in Great Britain. This work is licensed under a Creative Commons Attribution 4.0 International License.
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