Biological roles and delivery strategies for ions to promote osteogenic induction
Autor/a
Bosch-Rué, Elia
Diez-Tercero, Leire
Giordano-Kelhoffer, Barbara
Delgado, Luis M.
Bosch Canals, Begoña María
Hoyos Nogués, Mireia
Mateos-Timoneda, Miguel Angel
Tran, Phong A.
Gil Mur, Francisco Javier
Pérez Antoñanzas, Roman
Fecha de publicación
2021-01-14ISSN
2296-634X
Resumen
Bone is the most studied tissue in the field of tissue regeneration. Even though it has intrinsic capability to regenerate upon injury, several pathologies and injuries could hamper the highly orchestrated bone formation and resorption process. Bone tissue engineering seeks to mimic the extracellular matrix of the tissue and the different biochemical pathways that lead to successful regeneration. For many years, the use of extrinsic factors (i.e., growth factors and drugs) to modulate these biological processes have been the preferred choice in the field. Even though it has been successful in some instances, this approach presents several drawbacks, such as safety-concerns, short release profile and half-time life of the compounds. On the other hand, the use of inorganic ions has attracted significant attention due to their therapeutic effects, stability and lower biological risks. Biomaterials play a key role in such strategies where they serve as a substrate for the incorporation and release of the ions. In this review, the methodologies used to incorporate ions in biomaterials is presented, highlighting the osteogenic properties of such ions and the roles of biomaterials in controlling their release.
Tipo de documento
Artículo
Versión del documento
Versión publicada
Lengua
Inglés
Materias (CDU)
61 - Medicina
616.7 - Patología de los órganos de la locomoción. Sistema locomotor y esquelético
Palabras clave
Ossos
Enginyeria de teixits
Materials biomèdics
Regeneració (Biologia)
Ions
Huesos
Tejidos
Materiales biomédicos
Regeneración (Biología)
Bones
Tissue engineering
Biomedical materials
Regeneration (Biology)
Ions
Páginas
19
Publicado por
Frontiers Media
Colección
8;
Publicado en
Frontiers in Cell and Developmental Biology
Citación
Bosch-Rué, Elia; Diez-Tercero, Leire; Giordano-Kelhoffer, Barbara [et al.]. Biological roles and delivery strategies for ions to promote osteogenic induction. Frontiers in Cell and Developmental Biology, 2021, 8, 614545. Disponible en: <https://www.frontiersin.org/articles/10.3389/fcell.2020.614545/full>. Fecha de acceso: 5 feb. 2021. DOI: 10.3389/fcell.2020.614545
Este ítem aparece en la(s) siguiente(s) colección(ones)
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Derechos
© 2021 Bosch-Rué, Diez-Tercero, Giordano-Kelhoffer, Delgado, Bosch, Hoyos-Nogués,Mateos-Timoneda, Tran, Gil and Perez. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Excepto si se señala otra cosa, la licencia del ítem se describe como https://creativecommons.org/licenses/by/4.0/