Biological roles and delivery strategies for ions to promote osteogenic induction
Author
Bosch-Rué, Elia
Diez-Tercero, Leire
Giordano-Kelhoffer, Barbara
Delgado, Luis M.
Bosch Canals, Begoña María
Hoyos Nogués, Mireia
Mateos-Timoneda, Miguel Angel
Tran, Phong A.
Gil Mur, Francisco Javier
Pérez Antoñanzas, Roman
Publication date
2021-01-14ISSN
2296-634X
Abstract
Bone is the most studied tissue in the field of tissue regeneration. Even though it has intrinsic capability to regenerate upon injury, several pathologies and injuries could hamper the highly orchestrated bone formation and resorption process. Bone tissue engineering seeks to mimic the extracellular matrix of the tissue and the different biochemical pathways that lead to successful regeneration. For many years, the use of extrinsic factors (i.e., growth factors and drugs) to modulate these biological processes have been the preferred choice in the field. Even though it has been successful in some instances, this approach presents several drawbacks, such as safety-concerns, short release profile and half-time life of the compounds. On the other hand, the use of inorganic ions has attracted significant attention due to their therapeutic effects, stability and lower biological risks. Biomaterials play a key role in such strategies where they serve as a substrate for the incorporation and release of the ions. In this review, the methodologies used to incorporate ions in biomaterials is presented, highlighting the osteogenic properties of such ions and the roles of biomaterials in controlling their release.
Document Type
Article
Document version
Published version
Language
English
Subject (CDU)
61 - Medical sciences
616.7 - Pathology of the organs of locomotion. Skeletal and locomotor systems
Keywords
Ossos
Enginyeria de teixits
Materials biomèdics
Regeneració (Biologia)
Ions
Huesos
Tejidos
Materiales biomédicos
Regeneración (Biología)
Bones
Tissue engineering
Biomedical materials
Regeneration (Biology)
Ions
Pages
19
Publisher
Frontiers Media
Collection
8;
Is part of
Frontiers in Cell and Developmental Biology
Citation
Bosch-Rué, Elia; Diez-Tercero, Leire; Giordano-Kelhoffer, Barbara [et al.]. Biological roles and delivery strategies for ions to promote osteogenic induction. Frontiers in Cell and Developmental Biology, 2021, 8, 614545. Disponible en: <https://www.frontiersin.org/articles/10.3389/fcell.2020.614545/full>. Fecha de acceso: 5 feb. 2021. DOI: 10.3389/fcell.2020.614545
This item appears in the following Collection(s)
- Ciències de la Salut [725]
Rights
© 2021 Bosch-Rué, Diez-Tercero, Giordano-Kelhoffer, Delgado, Bosch, Hoyos-Nogués,Mateos-Timoneda, Tran, Gil and Perez. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Except where otherwise noted, this item's license is described as https://creativecommons.org/licenses/by/4.0/