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dc.contributor.authorFadó Andrés, Rut
dc.contributor.authorRodríguez-Rodríguez, Rosalía
dc.contributor.authorCasals i Farré, Núria
dc.date.accessioned2021-01-12T14:59:10Z
dc.date.available2021-01-12T14:59:10Z
dc.date.issued2021-01
dc.identifier.citationFadó, Rut; Rodríguez-Rodríguez, Rosalía; Casals, Núria. The return of malonyl-CoA to the brain: cognition and other stories. Progress in Lipid Research, 2021, 81, [p. 1-11]. Disponible en: <https://www.sciencedirect.com/science/article/pii/S0163782720300515>. Fecha de acceso: 12 ene. 2021. DOI: 10.1016/j.plipres.2020.101071ca
dc.identifier.issn0163-7827ca
dc.identifier.urihttp://hdl.handle.net/20.500.12328/1881
dc.description.abstractNutrients, hormones and the energy sensor AMP-activated protein kinase (AMPK) tightly regulate the intracel-lular levels of the metabolic intermediary malonyl-CoA, which is a precursor of fatty acid synthesis and a negative regulator of fatty acid oxidation. In the brain, the involvement of malonyl-CoA in the control of food intake and energy homeostasis has been known for decades. However, recent data uncover a new role in cognition and brain development. The sensing of malonyl-CoA by carnitine palmitoyltransferase 1 (CPT1) pro-teins regulates a variety of functions, such as the fate of neuronal stem cell precursors, the motility of lysosomes in developing axons, the trafficking of glutamate receptors to the neuron surface (necessary for proper synaptic function) and the metabolic coupling between astrocytes and neurons. We discuss the relevance of those recent findings evidencing how nutrients and metabolic disorders impact cognition. We also enumerate all nutritional and hormonal conditions that are known to regulate malonyl-CoA levels in the brain, reflect on protein malo-nylation as a new post-translational modification, and give a reasoned vision of the opportunities and challenges that future research in the field could address.ca
dc.format.extent11ca
dc.language.isoengca
dc.publisherElsevierca
dc.relation.ispartofProgress in Lipid Researchca
dc.relation.ispartofseries81;
dc.rights© 2020 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license(http://creativecommons.org/licenses/by-nc-nd/4.0/).ca
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.otherCognicióca
dc.subject.otherCervell
dc.subject.otherMetabolisme
dc.subject.otherCognición
dc.subject.otherCerebro
dc.subject.otherMetabolismo
dc.subject.otherCognition
dc.subject.otherBrain
dc.subject.otherMetabolism
dc.titleThe return of malonyl-CoA to the brain: cognition and other storiesca
dc.typeinfo:eu-repo/semantics/articleca
dc.description.versioninfo:eu-repo/semantics/publishedVersionca
dc.rights.accessLevelinfo:eu-repo/semantics/openAccess
dc.embargo.termscapca
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/2PE/SAF2017-83813- C3-3-Rca
dc.subject.udc61ca
dc.identifier.doihttps://dx.doi.org/10.1016/j.plipres.2020.101071ca


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© 2020 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license(http://creativecommons.org/licenses/by-nc-nd/4.0/).
Excepte que s'indiqui una altra cosa, la llicència de l'ítem es descriu com http://creativecommons.org/licenses/by/4.0/
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