Ultrasensitive photonic microsystem enabling sub-micrometric monitoring of arterial oscillations for advanced cardiovascular studies
Autor/a
Rodríguez-Rodríguez, Rosalía
Nils Ackermann, Tobias
Plaza, Jose Antonio
Simonsen, Ulf
Matchkov, Vladimir
Llobera, Andreu
Munoz-Berbel, Xavier
Data de publicació
2019-07-23ISSN
1664-042X
Resum
Cardiovascular diseases are the first cause of death globally. Their early diagnosis requires ultrasensitive tools enabling the detection of minor structural and functional alterations in small arteries. Such analyses have been traditionally performed with video imaging-based myographs, which helped to investigate the pathophysiology of the microvessels. Since new vascular questions have emerged, substantial modifications are necessary to improve the performance of imaging and tracking software, reducing the cost and minimizing the microvessel cleaning and manipulation. To address these limitations, we present a photonic microsystem fabricated in polydimethylsiloxane and integrating micro-optical elements and a lightguide-cantilever for sub-micrometric analysis of small arteries (between 125 and 400μm of basal diameter). This technology enables simultaneous measurement of arterial distension, stiffness, vasomotion, and heartbeat and without the need for advanced imaging system. The microsystem has a limit of detection of 2μm, five times lower than video imaging-based myographs, is two times more sensitive than them (0.5 μm/mmHg), reduces variability to half and doubles the linear range reported in these myographs. More importantly, it allows the analysis of intact arteries preserving the integrity and function of surrounding tissues. Assays can be conducted in three configurations according to the surrounding tissue: (i) isolated arteries (in vitro) where the surrounding tissue is partially removed, (ii) non-isolated arteries (in vivo) with surrounding tissue partially removed, and (iii) intact arteries in vivo preserving surrounding tissue as well as function and integrity. This technology represents a step forward in the prediction of cardiovascular risk.
Tipus de document
Article
Versió del document
Versió acceptada
Llengua
English
Matèries (CDU)
61 - Medicina
Paraules clau
Vasos sanguinis
Òptica integrada
Litografia
Vasos sanguíneos
Óptica integrada
Litografía
Blood vessels
Lithography
Integrated optics
Pàgines
11
Publicat per
Frontiers Media
Col·lecció
10;
Publicat a
Frontiers in Physiology
Citació
Rodríguez-Rodríguez, Rosalía; Nils Ackermann, Tobias; Plaza, Jose Antoni [et al.]. Ultrasensitive photonic microsystem enabling sub-micrometric monitoring of arterial oscillations for advanced cardiovascular studies. Frontiers in Physiology, 2019, vol. 10, p. 1-11. Disponible en: <https://www.frontiersin.org/articles/10.3389/fphys.2019.00940/full>. Fecha de acceso: 18 ene. 2020. DOI: 10.3389/fphys.2019.00940.
Número de l'acord de la subvenció
info:eu-repo/grantAgreement/ES/1PE/TEC2014-51940-C2
Aquest element apareix en la col·lecció o col·leccions següent(s)
- Ciències de la Salut [740]
Drets
© 2019 Rodríguez-Rodríguez, Ackermann, Plaza, Simonsen, Matchkov, Llobera and Munoz-Berbel. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Excepte que s'indiqui una altra cosa, la llicència de l'ítem es descriu com https://creativecommons.org/licenses/by/4.0/