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dc.contributor.authorRodríguez-Rodríguez, Rosalía
dc.contributor.authorNils Ackermann, Tobias
dc.contributor.authorPlaza, Jose Antonio
dc.contributor.authorSimonsen, Ulf
dc.contributor.authorMatchkov, Vladimir
dc.contributor.authorLlobera, Andreu
dc.contributor.authorMunoz-Berbel, Xavier
dc.date.accessioned2020-01-18T15:45:41Z
dc.date.available2020-01-18T15:45:41Z
dc.date.issued2019-07-23
dc.identifier.citationRodríguez-Rodríguez, Rosalía; Nils Ackermann, Tobias; Plaza, Jose Antoni [et al.]. Ultrasensitive photonic microsystem enabling sub-micrometric monitoring of arterial oscillations for advanced cardiovascular studies. Frontiers in Physiology, 2019, vol. 10, p. 1-11. Disponible en: <https://www.frontiersin.org/articles/10.3389/fphys.2019.00940/full>. Fecha de acceso: 18 ene. 2020. DOI: 10.3389/fphys.2019.00940.ca
dc.identifier.issn1664-042Xca
dc.identifier.urihttp://hdl.handle.net/20.500.12328/1423
dc.description.abstractCardiovascular diseases are the first cause of death globally. Their early diagnosis requires ultrasensitive tools enabling the detection of minor structural and functional alterations in small arteries. Such analyses have been traditionally performed with video imaging-based myographs, which helped to investigate the pathophysiology of the microvessels. Since new vascular questions have emerged, substantial modifications are necessary to improve the performance of imaging and tracking software, reducing the cost and minimizing the microvessel cleaning and manipulation. To address these limitations, we present a photonic microsystem fabricated in polydimethylsiloxane and integrating micro-optical elements and a lightguide-cantilever for sub-micrometric analysis of small arteries (between 125 and 400μm of basal diameter). This technology enables simultaneous measurement of arterial distension, stiffness, vasomotion, and heartbeat and without the need for advanced imaging system. The microsystem has a limit of detection of 2μm, five times lower than video imaging-based myographs, is two times more sensitive than them (0.5 μm/mmHg), reduces variability to half and doubles the linear range reported in these myographs. More importantly, it allows the analysis of intact arteries preserving the integrity and function of surrounding tissues. Assays can be conducted in three configurations according to the surrounding tissue: (i) isolated arteries (in vitro) where the surrounding tissue is partially removed, (ii) non-isolated arteries (in vivo) with surrounding tissue partially removed, and (iii) intact arteries in vivo preserving surrounding tissue as well as function and integrity. This technology represents a step forward in the prediction of cardiovascular risk.ca
dc.format.extent11ca
dc.language.isoengca
dc.publisherFrontiers Mediaca
dc.relation.ispartofFrontiers in Physiologyca
dc.relation.ispartofseries10;
dc.rights© 2019 Rodríguez-Rodríguez, Ackermann, Plaza, Simonsen, Matchkov, Llobera and Munoz-Berbel. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.ca
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subject.otherVasos sanguinisca
dc.subject.otherÒptica integrada
dc.subject.otherLitografia
dc.subject.otherVasos sanguíneos
dc.subject.otherÓptica integrada
dc.subject.otherLitografía
dc.subject.otherBlood vessels
dc.subject.otherLithography
dc.subject.otherIntegrated optics
dc.titleUltrasensitive photonic microsystem enabling sub-micrometric monitoring of arterial oscillations for advanced cardiovascular studiesca
dc.typeinfo:eu-repo/semantics/articleca
dc.description.versioninfo:eu-repo/semantics/acceptedVersionca
dc.embargo.termscapca
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/1PE/TEC2014-51940-C2ca
dc.subject.udc61ca
dc.identifier.doihttps://dx.doi.org/10.3389/fphys.2019.00940ca


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© 2019 Rodríguez-Rodríguez, Ackermann, Plaza, Simonsen, Matchkov, Llobera and Munoz-Berbel. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Except where otherwise noted, this item's license is described as https://creativecommons.org/licenses/by/4.0/
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