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Ghrelin causes a decline in GABA release by reducing fatty acid oxidation in cortex
(Molecular Neurobiology, 2018)
Lipid metabolism, specifically fatty acid oxidation (FAO) mediated by carnitine palmitoyltransferase (CPT) 1A, has been described to be an important actor of ghrelin action in hypothalamus. However, it ...
Novel regulation of the synthesis of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor subunit gluA1 by carnitine palmitoyltransferase 1C (CPT1C) in the hippocampus
(American Society for Biochemistry and Molecular Biology, 2015-10-16)
The regulation of AMPA-type receptor (AMPAR) abundance in the postsynaptic membrane is an important mechanism involved in learning and memory formation. Recent data suggest that one of the constituents ...
Predicting response trajectories during cognitive-behavioural therapy for panic disorder: no association with the BDNF gene or childhood maltreatment
(Public Library of Science, 2016)
Background: Anxiety disorders are highly prevalent and result in low quality of life and a high social and economic cost. The efficacy of cognitive-behavioural therapy (CBT) for anxiety disorders is ...
Thermal and non-thermal effects of capacitive–resistive electric transfer application on different structures of the knee: a cadaveric study
(Springer Nature, 2020)
Capacitive–resistive electric transfer therapy is used in physical rehabilitation and sports medicine to treat muscle, bone, ligament and tendon injuries. The purpose is to analyze the temperature change ...
Scoping review on interventions to improve adherence to reporting guidelines in health research
(BMJ Publishing Group, 2019)
Objectives: The goal of this study is to identify, analyse and classify interventions to improve adherence to reporting guidelines in order to obtain a wide picture of how the problem of enhancing the ...
High red blood cell distribution width as a marker of hospital mortality after ICU discharge: a cohort study
(Springer Nature, 2018-11-16)
Background: High red blood cell distribution width (RDW) is associated with worse outcome in diverse scenarios, including in critical illness. The Sabadell score (SS) predicts in-hospital survival after ...
Sensing of nutrients by CPT1C controls SAC1 activity to regulate AMPA receptor trafficking
(Rockefeller University Press, 2020-09)
Carnitine palmitoyltransferase 1C (CPT1C) is a sensor of malonyl-CoA and is located in the ER of neurons. AMPA receptors (AMPARs) mediate fast excitatory neurotransmission in the brain and play a key ...
Current challenges for targeting brown fat thermogenesis to combat obesity
(Frontiers Media S.A., 2020-10-27)
Just over a decade has passed since metabolically active brown adipose tissue (BAT) was unequivocally identified in healthy adult humans. Since then, researchers have provided evidence of expression of ...
The critical size is set at a single-cell level by growth rate to attain homeostasis and adaptation
(Nature Research, 2012-08-21)
Budding yeast cells are assumed to trigger Start and enter the cell cycle only after they attain a critical size set by external conditions. However, arguing against deterministic models of cell size ...
Effects of autologous adipose-derived regenerative stem cells administered at the time of anterior cruciate ligament reconstruction on knee function and graft healing
(SAGE Publications, 2019)
Purpose: To compare the healing and clinical outcomes of anterior cruciate ligament (ACL) reconstruction between patients with or without intraoperative administration of adipose-derived regenerative ...