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CPT1C promotes human mesenchymal stem cells survival under glucose deprivation through the modulation of autophagy
(Nature Research, 2018-05-03)
Human mesenchymal stem cells (hMSCs) are widely used in regenerative medicine. In some
applications, they must survive under low nutrient conditions engendered by avascularity. Strategies to
improve ...
Sensing of nutrients by CPT1C regulates late endosome/lysosome anterograde transport and axon growth
(eLife Sciences Publications, 2019)
Anterograde transport of late endosomes or lysosomes (LE/Lys) is crucial for proper axon growth. However, the role of energetic nutrients has been poorly explored. Malonyl-CoA is a precursor of fatty ...