Browsing Ciències de la Salut by Subject "Neurones"

Now showing items 1-10 of 10

    • Carnitine palmitoyltransferase 1C negatively regulates the endocannabinoid hydrolase ABHD6 in mice, depending on nutritional status 

      Miralpeix Monclús, Cristina; Reguera, Ana Cristina; Fosch, Anna; Casas, Maria; Lillo, Jaume; Navarro, Gemma; Franco, Rafael; Casas, Josefina; Alexander, Stephen P.H.; Casals i Farré, Núria; Rodríguez-Rodríguez, Rosalía (British Journal of Pharmacology, 2021-01)
      Background and Purpose: The enzyme α/β‐hydrolase domain containing 6 (ABHD6), a new member of the endocannabinoid system, is a promising therapeutic target against neuronal‐related diseases. However, ...

    • CPT1c is localized in endoplasmic reticulum of neurons and has carnitine palmitoyltransferase activity 

      Sierra, Adriana Y.; Gratacòs-Batlle, Esther; Carrasco, Patricia; Clotet Erra, Josep; Ureña, Jesús; Serra, Dolors; Asins, Guillermina; Hegardt, Fausto G.; Casals i Farré, Núria (Journal of Biological Chemistry, 2008)
      CPT1c is a carnitine palmitoyltransferase 1 (CPT1) isoform that is expressed only in the brain. The enzyme has recently been localized in neuron mitochondria. Although it has high sequence identity with ...

    • Ghrelin causes a decline in GABA release by reducing fatty acid oxidation in cortex 

      Mir, Joan Francesc; Zagmutt, Sebastián; Lichtenstein, Mathieu P.; García-Villoria, Judit; Weber, Minéia; Gracia, Ana; Fabriàs, Gemma; Casas, Josefina; López, Miguel; Casals i Farré, Núria; Ribes, Antònia; Suñol, Cristina; Herrero Rodríguez, Laura; Serra, Dolors (Springer Nature, 2018)
      Lipid metabolism, specifically fatty acid oxidation (FAO) mediated by carnitine palmitoyltransferase (CPT) 1A, has been described to be an important actor of ghrelin action in hypothalamus. However, it ...

    • Hypothalamic AMPK-ER Stress-JNK1 axis mediates the central actions of thyroid hormones on energy balance 

      Martinez-Sanchez, Noelia; Seoane-Collazo, Patricia; Contreras, Cristina; Varela, Luis; Villarroya, Joan; Rial-Pensado, Eva; Buque, Xabier; Aurrekoetxea, Igor; Delgado, Teresa C.; Vazquez-Martinez, Rafael; Gonzalez-Garcia, Ismael; Roa, Juan; Whittle, Andrew J.; Gomez-Santos, Beatriz; Velagapudi, Vidya; Loraine Tung, Y. C.; Morgan, Donald A.; Voshol, Peter J.; Martinez de Morentin, Pablo B.; Lopez-Gonzalez, Tania; Linares-Pose, Laura; Gonzalez, Francisco; Chatterjee, Krishna; Sobrino, Tomas; Medina-Gomez, Gema; Davis, Roger J.; Casals i Farré, Núria; Oresic, Matej; Coll, Anthony P.; Vidal-Puig, Antonio; Mittag, Jens; Tena-Sempere, Manuel; Malagon, Maria M.; Dieguez, Carlos; Martinez-Chantar, Maria Luz; Aspichueta, Patricia; Rahmouni, Kamal; Nogueiras, Rubén; Sabio, Guadalupe; Villarroya, Francesc; Lopez, Miguel (Cell Metabolism, 2017-07)
      Thyroid hormones (THs) act in the brain to modulate energy balance. We show that central triiodothyronine (T3) regulates de novo lipogenesis in liver and lipid oxidation in brown adipose tissue (BAT) ...

    • Induction of ER stress in response to oxygen-glucose deprivation of cortical cultures involves the activation of the PERK and IRE-1 pathways and of caspase-12 

      Badiola, Nahuai; Penas, Clara; Miñano Molina, Alfredo Jesús; Barneda-Zahonero, Bruna; Fadó Andrés, Rut; Sánchez-Opazo, G.; Comella, Joan X.; Sabrià, Josefa; Zhu, Chuanshuai; Blomgren, Klas; Casas, Caty; Rodríguez-Álvarez, José (Cell Death and Disease, 2011-04-28)
      Disturbance of calcium homeostasis and accumulation of misfolded proteins in the endoplasmic reticulum (ER) are considered contributory components of cell death after ischemia. However, the signal-transducing ...

    • Mechanisms of CPT1C-Dependent AMPAR trafficking enhancement 

      Gratacòs-Batlle, Esther; Olivella, Mireia; Sánchez-Fernández, Nuria; Yefimenko, Natalia; MIguez-Cabello, Federico; Fadó Andrés, Rut; Casals i Farré, Núria; Gasull, Xavier; Ambrosio, Santiago; Soto, David (Frontiers in Molecular Neuroscience, 2018-08-08)
      In neurons, AMPA receptor (AMPAR) function depends essentially on their constituent components: the ion channel forming subunits and ion channel associated proteins. On the other hand, AMPAR trafficking ...

    • Nurr1 protein Is required for N-methyl-d-aspartic acid (NMDA) receptor-mediated neuronal survival 

      Barneda-Zahonero, Bruna; Servitja, Joan-Marc; Badiola, Nahuai; Miñano Molina, Alfredo Jesús; Fadó Andrés, Rut; Saura, Carlos A.; Rodríguez-Álvarez, José (Journal of Biological Chemistry, 2012-03-30)
      NMDA receptor (NMDAR) stimulation promotes neuronal survival during brain development. Cerebellar granule cells (CGCs) need NMDAR stimulation to survive and develop. These neurons differentiate and ...

    • Sensing of nutrients by CPT1C controls SAC1 activity to regulate AMPA receptor trafficking 

      Casas, Maria; Rut, Fadó; Domínguez, José Luis; Roig, Aina; Kaku, Moena; Chohnan, Shigeru; Solé, Montse; Unzeta, Mercedes; Miñano Molina, Alfredo Jesús; Rodríguez-Álvarez, José; James Dickson, Eamonn; Casals i Farré, Núria (Journal of Cell Biology, 2020-09)
      Carnitine palmitoyltransferase 1C (CPT1C) is a sensor of malonyl-CoA and is located in the ER of neurons. AMPA receptors (AMPARs) mediate fast excitatory neurotransmission in the brain and play a key ...

    • Sensing of nutrients by CPT1C controls SAC1 activity to regulate AMPA receptor trafficking 

      Casas, Maria; Fadó Andrés, Rut; Domínguez, José Luis; Roig, Aina; Kaku, Moena; Chohnan, Shigeru; Solé, Montse; Unzeta, Mercedes; Miñano Molina, Alfredo Jesús; Rodríguez-Álvarez, José; Dickson, Eamonn James; Casals i Farré, Núria (Journal of Cell Biology, 2020)
      Carnitine palmitoyltransferase 1C (CPT1C) is a sensor of malonyl-CoA and is located in the ER of neurons. AMPA receptors (AMPARs) mediate fast excitatory neurotransmission in the brain and play a key ...

    • Sensing of nutrients by CPT1C regulates late endosome/lysosome anterograde transport and axon growth 

      Palomo Guerrero, Marta; Fadó Andrés, Rut; Casas, Maria; Pérez-Montero, Marta; Baena, Miguel; Helmer, Patrick O.; Domínguez, José Luis; Roig, Aina; Serra, Dolors; Hayen, Heiko; Stenmark, Harald; Raiborg, Camilla; Casals i Farré, Núria (eLife, 2019)
      Anterograde transport of late endosomes or lysosomes (LE/Lys) is crucial for proper axon growth. However, the role of energetic nutrients has been poorly explored. Malonyl-CoA is a precursor of fatty ...