Competition in the chaperone-client network subordinates cell-cycle entry to growth and stress
Autor/a
Moreno, David F.
Parisi, Eva
Yahya, Galal
Vaggi, Federico
Csikász-Nagy, Attila
Aldea Malo, Martí
Fecha de publicación
2019-04-15ISSN
2575-1077
Resumen
The precise coordination of growth and proliferation has a
universal prevalence in cell homeostasis. As a prominent
property, cell size is modulated by the coordination between
these processes in bacterial, yeast, and mammalian cells, but
the underlying molecular mechanisms are largely unknown.
Here, we show that multifunctional chaperone systems play a
concerted and limiting role in cell-cycle entry, specifically
driving nuclear accumulation of the G1 Cdk–cyclin complex.
Based on these findings, we establish and test a molecular
competition model that recapitulates cell-cycle-entry dependence on growth rate. As key predictions at a single-cell
level, we show that availability of the Ydj1 chaperone and nuclear accumulation of the G1 cyclin Cln3 are inversely dependent
on growth rate and readily respond to changes in protein
synthesis and stress conditions that alter protein folding requirements. Thus, chaperone workload would subordinate Start
to the biosynthetic machinery and dynamically adjust proliferation to the growth potential of the cell.
Tipo de documento
Artículo
Versión del documento
Versión aceptada
Lengua
Inglés
Materias (CDU)
61 - Medicina
Palabras clave
Cicle cel·lular
Cell cycle
Cells
Cells--Growth-Molecular aspects
Células
Cèl·lules
Cèl·lules--Creixement--Aspectes moleculars
Páginas
16
Publicado por
Life Science Alliance
Colección
2;2
Publicado en
Life Science Alliance
Citación
Moreno, David F.; Parisi, Eva; Yahya, Galal; Vaggi, Federico; Csikasz-Nagy, Attila; Aldea Malo, Martí. «Competition in the chaperone-client network subordinates cell-cycle entry to growth and stress». Life Science Alliance, 2019, vol. 2, núm. 2, art. e201800277. Disponible en: <https://www.life-science-alliance.org/content/2/2/e201800277/tab-rc>. Fecha de acceso: 24 oct. 2019. DOI: 10.26508/lsa.201800277
Este ítem aparece en la(s) siguiente(s) colección(ones)
- Ciències de la Salut [712]
Derechos
http://creativecommons.org/licenses/by-nc-nd/4.0/
El ítem tiene asociados los siguientes ficheros de licencia:
Excepto si se señala otra cosa, la licencia del ítem se describe como http://creativecommons.org/licenses/by-nc-nd/4.0/