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dc.contributor.authorMoreno, David F.
dc.contributor.authorParisi, Eva
dc.contributor.authorYahya, Galal
dc.contributor.authorVaggi, Federico
dc.contributor.authorCsikasz-Nagy, Attila
dc.contributor.authorAldea Malo, Martí
dc.date.accessioned2019-10-24T15:09:45Z
dc.date.available2019-10-24T15:09:45Z
dc.date.issued2019-04-15
dc.identifier.citationMoreno, David F.; Parisi, Eva; Yahya, Galal; Vaggi, Federico; Csikasz-Nagy, Attila; Aldea Malo, Martí. «Competition in the chaperone-client network subordinates cell-cycle entry to growth and stress». Life Science Alliance, 2019, vol. 2, núm. 2, art. e201800277. Disponible en: <https://www.life-science-alliance.org/content/2/2/e201800277/tab-rc>. Fecha de acceso: 24 oct. 2019. DOI: 10.26508/lsa.201800277ca
dc.identifier.issn2575-1077ca
dc.identifier.urihttp://hdl.handle.net/20.500.12328/1271
dc.description.abstractThe precise coordination of growth and proliferation has a universal prevalence in cell homeostasis. As a prominent property, cell size is modulated by the coordination between these processes in bacterial, yeast, and mammalian cells, but the underlying molecular mechanisms are largely unknown. Here, we show that multifunctional chaperone systems play a concerted and limiting role in cell-cycle entry, specifically driving nuclear accumulation of the G1 Cdk–cyclin complex. Based on these findings, we establish and test a molecular competition model that recapitulates cell-cycle-entry dependence on growth rate. As key predictions at a single-cell level, we show that availability of the Ydj1 chaperone and nuclear accumulation of the G1 cyclin Cln3 are inversely dependent on growth rate and readily respond to changes in protein synthesis and stress conditions that alter protein folding requirements. Thus, chaperone workload would subordinate Start to the biosynthetic machinery and dynamically adjust proliferation to the growth potential of the cell.ca
dc.format.extent16ca
dc.language.isoengca
dc.publisherLife Science Allianceca
dc.relation.ispartofLife Science Allianceca
dc.relation.ispartofseries2;2
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/4.0/ca
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subject.otherCicle cel·lularca
dc.subject.otherCell cycleca
dc.subject.otherCellsca
dc.subject.otherCells--Growth-Molecular aspectsca
dc.subject.otherCélulasca
dc.subject.otherCèl·lulesca
dc.subject.otherCèl·lules--Creixement--Aspectes molecularsca
dc.titleCompetition in the chaperone-client network subordinates cell-cycle entry to growth and stressca
dc.typeinfo:eu-repo/semantics/articleca
dc.description.versioninfo:eu-repo/semantics/acceptedVersionca
dc.embargo.termscapca
dc.subject.udc61ca
dc.identifier.doihttps://doi.org/10.26508/lsa.201800277ca


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