Antimicrobial peptides: powerful biorecognition elements to detect bacteria in biosensing technologies
Author
Hoyos Nogués, Mireia
Gil Mur, Francisco Javier
Mas Moruno, Carlos
Publication date
2018-07-10ISSN
1420-3049
Abstract
Bacterial infections represent a serious threat in modern medicine. In particular, biofilm
treatment in clinical settings is challenging, as biofilms are very resistant to conventional antibiotic
therapy and may spread infecting other tissues. To address this problem, biosensing technologies are
emerging as a powerful solution to detect and identify bacterial pathogens at the very early stages of
the infection, thus allowing rapid and effective treatments before biofilms are formed. Biosensors
typically consist of two main parts, a biorecognition moiety that interacts with the target (i.e., bacteria)
and a platform that transduces such interaction into a measurable signal. This review will focus on
the development of impedimetric biosensors using antimicrobial peptides (AMPs) as biorecognition
elements. AMPs belong to the innate immune system of living organisms and are very effective in
interacting with bacterial membranes. They offer unique advantages compared to other classical
bioreceptor molecules such as enzymes or antibodies. Moreover, impedance-based sensors allow the
development of label-free, rapid, sensitive, specific and cost-effective sensing platforms. In summary,
AMPs and impedimetric transducers combine excellent properties to produce robust biosensors for
the early detection of bacterial infections.
Document Type
Review
Document version
Accepted version
Language
English
Subject (CDU)
577 - Material bases of life. Biochemistry. Molecular biology. Biophysics
Keywords
Bacteris
Bacteria
Bacterias
Biosensors
Biosensores
Espectroscòpia d'impedància
Impedance spectroscopy
Pages
24
Publisher
MDPI
Collection
23; 7
Is part of
Molecules
Citation
Hoyos Nogués, Mireia; Gil Mur, Francesc Xavier; Mas Moruno, Carlos. «Antimicrobial peptides: powerful biorecognition elements to detect bacteria in biosensing technologies». Molecules, 2018, vol. 23, núm. 7, 1683. Disponible en: <https://www.mdpi.com/1420-3049/23/7/1683>. Fecha de acceso: 20 sept. 2019. https://doi.org/10.3390/molecules23071683
Note
This article belongs to the Special Issue Antimicrobial Peptides and Peptidomimetics
This item appears in the following Collection(s)
- Ciències de la Salut [740]
Rights
http://creativecommons.org/licenses/by-nc-nd/4.0/
Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by-nc-nd/4.0/