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Hypothalamic regulation of obesity
(MDPI, 2021)
Obesity has now reached pandemic proportions and represents a major socioeconomic and health problem in our societies. Up to now, obesity has been considered a medical issue only in high-income countries, ...
A self-calibrating and multiplexed electrochemical lab-on-a-chip for cell culture analysis and high-resolution imaging
(Royal Society of Chemistry, 2020)
In vitro analysis requires cell proliferation in conditions close to physiological ones. Lab-on-a-chip (LoC) devices simplify, miniaturize and automate traditional protocols, with the advantages of being ...
Critical update for the clinical use of L-carnitine analogs in cardiometabolic disorders
(Dove Press, 2011-03-28)
Acetyl-L-carnitine (ALC) and propionyl-L-carnitine (PLC) are two naturally occurring carnitine derivates formed by carnitine acetyltransferase. The beneficial cardiovascular effects of ALC and PLC have ...
CPT1C in the ventromedial nucleus of the hypothalamus is necessary for brown fat thermogenesis activation in obesity
(Elsevier, 2019-01)
Objective: Carnitine palmitoyltransferase 1C (CPT1C) is implicated in central regulation of energy homeostasis. Our aim was to investigate whether CPT1C in the ventromedial nucleus of the hypothalamus ...
Editorial: current challenges for targeting brown fat thermogenesis to combat obesity
(Frontiers Media, 2020-10-27)
Just over a decade has passed since metabolically active brown adipose tissue (BAT) was unequivocally identified in healthy adult humans. Since then, researchers have provided evidence of expression of ...
Ultrasensitive photonic microsystem enabling sub-micrometric monitoring of arterial oscillations for advanced cardiovascular studies
(Frontiers Media, 2019-07-23)
Cardiovascular diseases are the first cause of death globally. Their early diagnosis requires ultrasensitive tools enabling the detection of minor structural and functional alterations in small arteries. ...
The return of malonyl-CoA to the brain: cognition and other stories
(Elsevier, 2021-01)
Nutrients, hormones and the energy sensor AMP-activated protein kinase (AMPK) tightly regulate the intracel-lular levels of the metabolic intermediary malonyl-CoA, which is a precursor of fatty ...
Potential vasorelaxant effects of oleanolic acid and erythrodiol, two triterpenoids contained in ‘orujo’ olive oil, on rat aorta
(Cambridge University Press, 2004)
‘Orujo’ olive oil is obtained by chemical processes from the waste resulting from the mechanical extraction of virgin olive oil. The aim of the present study was to evaluate a new pharmacological property ...
Astrocytes and oligodendrocytes in grey and white matter regions of the brain metabolize fatty acids
(Springer Nature, 2017-09-07)
The grey and white matter regions of the mammalian brain consist of both neurons and neuroglial cells. Among the neuroglia, the two macroglia oligodendrocytes and astrocytes are the most abundant cell ...
Sonochemical coating of Prussian Blue for the production of smart bacterial-sensing hospital textiles
(Elsevier, 2021-01)
In healthcare facilities, environmental microbes are responsible for numerous infections leading to patient’s health complications and even death. The detection of the pathogens present on contaminated ...